Detailed information of TA system TA026241

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 415609..416233
• Replicon: chromosome
• Accession: NC_017063
• Organism: Helicobacter pylori ELS37

Toxin (Protein)

• Gene name: relE
• Uniprot ID: H8H8H6
• Locus tag: HPELS_RS02035
• Protein ID: WP_013356424.1
• Coordinates: 415967..416233 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H8H8H5
• Locus tag: HPELS_RS02030
• Protein ID: WP_001134039.1
• Coordinates: 415609..415986 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPELS_RS08165	411312..411710	+	399	WP_080012187.1	hypothetical protein	-
HPELS_RS02025	412753..414882	+	2130	WP_000716244.1	Hop family adhesin BabB	-
HPELS_RS02030	415609..415986	+	378	WP_001134039.1	hypothetical protein	Antitoxin
HPELS_RS02035	415967..416233	+	267	WP_013356424.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPELS_RS02040	416312..416542	+	231	WP_014419523.1	hypothetical protein	-
HPELS_RS02045	416577..416807	-	231	WP_000269326.1	hypothetical protein	-
HPELS_RS02050	416931..417210	+	280	Protein_371	virulence associated protein VapD	-
HPELS_RS02055	417406..417930	-	525	WP_001135624.1	acyl-CoA thioesterase	-
HPELS_RS02060	418070..418924	+	855	WP_000538078.1	SDR family oxidoreductase	-
HPELS_RS02065	418917..419897	+	981	WP_000921461.1	iron ABC transporter permease	-
HPELS_RS02070	419897..420664	+	768	WP_000242348.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10390.29 Da
• Isoelectric Point: 9.6286

>T26241 WP_013356424.1 NC_017063:415967-416233 [Helicobacter pylori ELS37]
VLKLNLKKSFQKDFDKLLLNGFDDSVLKEVILTLRKKEPLDPRFQDHALKGKWKPFRECHIKSDILLVYLVKDDELILLR
LGSHSELF

Nucleotide

• Length: 267 bp

>T26241 NC_017063:415967-416233 [Helicobacter pylori ELS37]
GTGTTGAAGCTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAAGGAAGTCATTCTAACCTTAAGAAAAAAAGAACCGCTAGATCCACGATTTCAAGATCATGCCCTAAAAGGCAAGTGGA
AACCTTTTAGGGAATGCCATATTAAATCCGACATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTGATTTTGTTAAGG
TTAGGCAGTCATAGTGAGTTGTTTTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14758.56 Da
• Isoelectric Point: 6.4787

>AT26241 WP_001134039.1 NC_017063:415609-415986 [Helicobacter pylori ELS37]
MPNTTAEKDYTKYSEKQLFNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCF
GHETPNIQTQQAMRDADNKETDLFVEDFSSYSNERKKALGVEAQS

Nucleotide

• Length: 378 bp

>AT26241 NC_017063:415609-415986 [Helicobacter pylori ELS37]
ATGCCTAACACCACCGCAGAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTT
GGGCATGAAACCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCGGATAACAAAGAAACAGATTTGTTCGTTGAGGA
TTTTTCTAGTTATAGCAATGAGAGAAAAAAGGCTTTAGGTGTTGAAGCTCAATCTTAA

Structures

Toxin

• AlphaFold DB: H8H8H6

Antitoxin

• AlphaFold DB: H8H8H5