Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1001467..1002121 Replicon chromosome
Accession NZ_CP109929
Organism Escherichia coli O6:K2:H1 strain C 691-04A

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag N8A71_RS04955 Protein ID WP_000244781.1
Coordinates 1001714..1002121 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N8A71_RS04950 Protein ID WP_000354046.1
Coordinates 1001467..1001733 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8A71_RS04930 (997555) 997555..998988 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
N8A71_RS04935 (999033) 999033..999344 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
N8A71_RS04940 (999508) 999508..1000167 + 660 WP_000250274.1 hemolysin III family protein -
N8A71_RS04945 (1000244) 1000244..1001224 - 981 WP_000886079.1 tRNA-modifying protein YgfZ -
N8A71_RS04950 (1001467) 1001467..1001733 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N8A71_RS04955 (1001714) 1001714..1002121 + 408 WP_000244781.1 protein YgfX Toxin
N8A71_RS04960 (1002161) 1002161..1002682 - 522 WP_001055874.1 flavodoxin FldB -
N8A71_RS04965 (1002794) 1002794..1003690 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N8A71_RS04970 (1003715) 1003715..1004425 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N8A71_RS04975 (1004431) 1004431..1006164 + 1734 WP_000813189.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T262396 WP_000244781.1 NZ_CP109929:1001714-1002121 [Escherichia coli O6:K2:H1]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT262396 WP_000354046.1 NZ_CP109929:1001467-1001733 [Escherichia coli O6:K2:H1]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References