Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2629612..2630250 Replicon chromosome
Accession NZ_CP109924
Organism Escherichia coli O125ac:K+:H10 strain C 236-04A

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N8A72_RS12815 Protein ID WP_000813794.1
Coordinates 2630074..2630250 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N8A72_RS12810 Protein ID WP_001270286.1
Coordinates 2629612..2630028 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8A72_RS12790 (2624764) 2624764..2625705 - 942 WP_001251313.1 ABC transporter permease -
N8A72_RS12795 (2625706) 2625706..2626719 - 1014 WP_000220434.1 ABC transporter ATP-binding protein -
N8A72_RS12800 (2626737) 2626737..2627882 - 1146 WP_000047430.1 ABC transporter substrate-binding protein -
N8A72_RS12805 (2628127) 2628127..2629533 - 1407 WP_000760630.1 PLP-dependent aminotransferase family protein -
N8A72_RS12810 (2629612) 2629612..2630028 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N8A72_RS12815 (2630074) 2630074..2630250 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N8A72_RS12820 (2630472) 2630472..2630702 + 231 WP_000494244.1 YncJ family protein -
N8A72_RS12825 (2630794) 2630794..2632755 - 1962 WP_001488038.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N8A72_RS12830 (2632828) 2632828..2633364 - 537 WP_000429169.1 DNA-binding transcriptional regulator SutR -
N8A72_RS12835 (2633456) 2633456..2634631 + 1176 WP_264454979.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T262385 WP_000813794.1 NZ_CP109924:c2630250-2630074 [Escherichia coli O125ac:K+:H10]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT262385 WP_001270286.1 NZ_CP109924:c2630028-2629612 [Escherichia coli O125ac:K+:H10]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References