Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 305403..306034 Replicon chromosome
Accession NZ_CP109924
Organism Escherichia coli O125ac:K+:H10 strain C 236-04A

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag N8A72_RS01365 Protein ID WP_001259385.1
Coordinates 305403..305678 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag N8A72_RS01370 Protein ID WP_000593555.1
Coordinates 305675..306034 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8A72_RS01350 (300407) 300407..301474 + 1068 WP_000361470.1 HlyD family secretion protein -
N8A72_RS01355 (301471) 301471..304206 + 2736 WP_000149123.1 ribosome-associated ATPase/putative transporter RbbA -
N8A72_RS01360 (304206) 304206..305330 + 1125 WP_001488398.1 ABC transporter permease -
N8A72_RS01365 (305403) 305403..305678 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
N8A72_RS01370 (305675) 305675..306034 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N8A72_RS01375 (306154) 306154..306555 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
N8A72_RS01380 (306561) 306561..307367 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
N8A72_RS01385 (307364) 307364..308128 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
N8A72_RS01390 (308128) 308128..308961 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
N8A72_RS01395 (308958) 308958..309902 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 285110..306034 20924


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T262371 WP_001259385.1 NZ_CP109924:305403-305678 [Escherichia coli O125ac:K+:H10]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT262371 WP_000593555.1 NZ_CP109924:305675-306034 [Escherichia coli O125ac:K+:H10]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References