Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4394702..4395199 Replicon chromosome
Accession NZ_CP109921
Organism Escherichia coli O2:K2:H1 strain C 237-04

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag N7L43_RS21305 Protein ID WP_001173343.1
Coordinates 4394702..4394875 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag N7L43_RS21310 Protein ID WP_001312331.1
Coordinates 4394903..4395199 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7L43_RS21295 (4391372) 4391372..4392829 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
N7L43_RS21300 (4393066) 4393066..4394583 + 1518 WP_000003806.1 lysine--tRNA ligase -
N7L43_RS21305 (4394702) 4394702..4394875 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
N7L43_RS21310 (4394903) 4394903..4395199 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
N7L43_RS21315 (4395428) 4395428..4395700 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
N7L43_RS21320 (4395712) 4395712..4395942 - 231 WP_000371715.1 4Fe-4S mono-cluster protein YjdI -
N7L43_RS21325 (4396123) 4396123..4397754 + 1632 WP_001216466.1 sensor histidine kinase -
N7L43_RS21330 (4397751) 4397751..4398470 + 720 WP_000611291.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T262369 WP_001173343.1 NZ_CP109921:c4394875-4394702 [Escherichia coli O2:K2:H1]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT262369 WP_001312331.1 NZ_CP109921:c4395199-4394903 [Escherichia coli O2:K2:H1]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References