Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3542484..3543102 Replicon chromosome
Accession NZ_CP109921
Organism Escherichia coli O2:K2:H1 strain C 237-04

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N7L43_RS17325 Protein ID WP_001291435.1
Coordinates 3542884..3543102 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N7L43_RS17320 Protein ID WP_000344800.1
Coordinates 3542484..3542858 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7L43_RS17310 (3537574) 3537574..3538767 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N7L43_RS17315 (3538790) 3538790..3541939 + 3150 WP_171854650.1 efflux RND transporter permease AcrB -
N7L43_RS17320 (3542484) 3542484..3542858 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N7L43_RS17325 (3542884) 3542884..3543102 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N7L43_RS17330 (3543275) 3543275..3543826 + 552 WP_000102539.1 maltose O-acetyltransferase -
N7L43_RS17335 (3543942) 3543942..3544412 + 471 WP_001304825.1 YlaC family protein -
N7L43_RS17340 (3544576) 3544576..3546126 + 1551 WP_001528761.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N7L43_RS17345 (3546168) 3546168..3546521 - 354 WP_000878140.1 DUF1428 domain-containing protein -
N7L43_RS17355 (3546900) 3546900..3547211 + 312 WP_000409908.1 MGMT family protein -
N7L43_RS17360 (3547242) 3547242..3547814 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T262360 WP_001291435.1 NZ_CP109921:3542884-3543102 [Escherichia coli O2:K2:H1]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT262360 WP_000344800.1 NZ_CP109921:3542484-3542858 [Escherichia coli O2:K2:H1]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References