Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1044799..1045453 Replicon chromosome
Accession NZ_CP109921
Organism Escherichia coli O2:K2:H1 strain C 237-04

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag N7L43_RS05180 Protein ID WP_000244781.1
Coordinates 1045046..1045453 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N7L43_RS05175 Protein ID WP_000354046.1
Coordinates 1044799..1045065 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7L43_RS05155 (1040887) 1040887..1042320 - 1434 WP_021519470.1 6-phospho-beta-glucosidase BglA -
N7L43_RS05160 (1042365) 1042365..1042676 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
N7L43_RS05165 (1042840) 1042840..1043499 + 660 WP_000250274.1 hemolysin III family protein -
N7L43_RS05170 (1043576) 1043576..1044556 - 981 WP_000886079.1 tRNA-modifying protein YgfZ -
N7L43_RS05175 (1044799) 1044799..1045065 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N7L43_RS05180 (1045046) 1045046..1045453 + 408 WP_000244781.1 protein YgfX Toxin
N7L43_RS05185 (1045493) 1045493..1046014 - 522 WP_001055874.1 flavodoxin FldB -
N7L43_RS05190 (1046126) 1046126..1047022 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N7L43_RS05195 (1047047) 1047047..1047757 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N7L43_RS05200 (1047763) 1047763..1049496 + 1734 WP_000813189.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T262353 WP_000244781.1 NZ_CP109921:1045046-1045453 [Escherichia coli O2:K2:H1]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT262353 WP_000354046.1 NZ_CP109921:1044799-1045065 [Escherichia coli O2:K2:H1]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References