Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4944146..4944732 Replicon chromosome
Accession NZ_CP109920
Organism Pseudomonas aeruginosa strain PALA39

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag PALA39_RS23330 Protein ID WP_003120987.1
Coordinates 4944433..4944732 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PALA39_RS23325 Protein ID WP_003448662.1
Coordinates 4944146..4944436 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA39_RS23305 (PALA39_04611) 4939297..4939506 + 210 WP_003105733.1 cold-shock protein -
PALA39_RS23310 (PALA39_04612) 4939728..4941617 + 1890 WP_016851610.1 hypothetical protein -
PALA39_RS23315 (PALA39_04613) 4941614..4943590 + 1977 WP_016851611.1 DEAD/DEAH box helicase -
PALA39_RS23320 4943731..4944075 + 345 WP_016851612.1 hypothetical protein -
PALA39_RS23325 (PALA39_04614) 4944146..4944436 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
PALA39_RS23330 (PALA39_04615) 4944433..4944732 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA39_RS23335 (PALA39_04616) 4944934..4946058 + 1125 WP_012076859.1 TcpQ domain-containing protein -
PALA39_RS23340 (PALA39_04617) 4946058..4947767 + 1710 WP_012076860.1 PilN family type IVB pilus formation outer membrane protein -
PALA39_RS23345 (PALA39_04618) 4947771..4949096 + 1326 WP_003099758.1 type 4b pilus protein PilO2 -
PALA39_RS23350 (PALA39_04619) 4949086..4949619 + 534 WP_003099760.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4917623..5011644 94021


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T262348 WP_003120987.1 NZ_CP109920:c4944732-4944433 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT262348 WP_003448662.1 NZ_CP109920:c4944436-4944146 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References