Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4869623..4870881 Replicon chromosome
Accession NZ_CP109920
Organism Pseudomonas aeruginosa strain PALA39

Toxin (Protein)


Gene name - Uniprot ID A0A241XTS2
Locus tag PALA39_RS22920 Protein ID WP_023464370.1
Coordinates 4869623..4870378 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A241XST8
Locus tag PALA39_RS22925 Protein ID WP_023464369.1
Coordinates 4870513..4870881 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA39_RS22910 (PALA39_04535) 4864794..4867337 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
PALA39_RS22915 (PALA39_04536) 4867492..4868853 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PALA39_RS22920 (PALA39_04537) 4869623..4870378 - 756 WP_023464370.1 RES family NAD+ phosphorylase Toxin
PALA39_RS22925 (PALA39_04538) 4870513..4870881 - 369 WP_023464369.1 DUF2384 domain-containing protein Antitoxin
PALA39_RS22930 (PALA39_04539) 4870954..4872240 - 1287 WP_023464368.1 FAD-binding oxidoreductase -
PALA39_RS22935 (PALA39_04540) 4872296..4873885 - 1590 WP_023464367.1 aldehyde dehydrogenase family protein -
PALA39_RS22940 (PALA39_04541) 4873963..4874439 + 477 WP_019725934.1 hypothetical protein -
PALA39_RS22945 4874442..4874717 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28226.37 Da        Isoelectric Point: 7.6839

>T262347 WP_023464370.1 NZ_CP109920:c4870378-4869623 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAECAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRASQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13395.68 Da        Isoelectric Point: 9.9874

>AT262347 WP_023464369.1 NZ_CP109920:c4870881-4870513 [Pseudomonas aeruginosa]
MSVLIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XTS2

Antitoxin

Source ID Structure
AlphaFold DB A0A241XST8

References