Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /Xre(antitoxin) |
Location | 4869623..4870881 | Replicon | chromosome |
Accession | NZ_CP109920 | ||
Organism | Pseudomonas aeruginosa strain PALA39 |
Toxin (Protein)
Gene name | - | Uniprot ID | A0A241XTS2 |
Locus tag | PALA39_RS22920 | Protein ID | WP_023464370.1 |
Coordinates | 4869623..4870378 (-) | Length | 252 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A0A241XST8 |
Locus tag | PALA39_RS22925 | Protein ID | WP_023464369.1 |
Coordinates | 4870513..4870881 (-) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PALA39_RS22910 (PALA39_04535) | 4864794..4867337 | + | 2544 | WP_003112526.1 | acyl-homoserine-lactone acylase QuiP | - |
PALA39_RS22915 (PALA39_04536) | 4867492..4868853 | - | 1362 | WP_003081943.1 | DNA recombination protein RmuC | - |
PALA39_RS22920 (PALA39_04537) | 4869623..4870378 | - | 756 | WP_023464370.1 | RES family NAD+ phosphorylase | Toxin |
PALA39_RS22925 (PALA39_04538) | 4870513..4870881 | - | 369 | WP_023464369.1 | DUF2384 domain-containing protein | Antitoxin |
PALA39_RS22930 (PALA39_04539) | 4870954..4872240 | - | 1287 | WP_023464368.1 | FAD-binding oxidoreductase | - |
PALA39_RS22935 (PALA39_04540) | 4872296..4873885 | - | 1590 | WP_023464367.1 | aldehyde dehydrogenase family protein | - |
PALA39_RS22940 (PALA39_04541) | 4873963..4874439 | + | 477 | WP_019725934.1 | hypothetical protein | - |
PALA39_RS22945 | 4874442..4874717 | - | 276 | WP_010792073.1 | zinc ribbon domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 252 a.a. Molecular weight: 28226.37 Da Isoelectric Point: 7.6839
>T262347 WP_023464370.1 NZ_CP109920:c4870378-4869623 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAECAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRASQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAECAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRASQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA
Download Length: 756 bp
Antitoxin
Download Length: 123 a.a. Molecular weight: 13395.68 Da Isoelectric Point: 9.9874
>AT262347 WP_023464369.1 NZ_CP109920:c4870881-4870513 [Pseudomonas aeruginosa]
MSVLIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV
MSVLIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV
Download Length: 369 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A241XTS2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A241XST8 |