Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3869234..3870455 Replicon chromosome
Accession NZ_CP109920
Organism Pseudomonas aeruginosa strain PALA39

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PALA39_RS18005 Protein ID WP_003102740.1
Coordinates 3869877..3870455 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA39_RS18000 Protein ID WP_003088112.1
Coordinates 3869234..3869788 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA39_RS17975 (PALA39_03566) 3864802..3865353 + 552 WP_003450159.1 XRE family transcriptional regulator -
PALA39_RS17980 (PALA39_03567) 3865350..3865748 - 399 WP_023082958.1 NADH-quinone oxidoreductase subunit A -
PALA39_RS17985 (PALA39_03568) 3865761..3866084 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA39_RS17990 (PALA39_03569) 3866415..3866876 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA39_RS17995 (PALA39_03570) 3866881..3869076 + 2196 WP_023464651.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA39_RS18000 (PALA39_03571) 3869234..3869788 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA39_RS18005 (PALA39_03572) 3869877..3870455 + 579 WP_003102740.1 HD domain-containing protein Toxin
PALA39_RS18010 (PALA39_03573) 3870564..3871751 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA39_RS18015 (PALA39_03574) 3871741..3873912 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
PALA39_RS18020 (PALA39_03575) 3873902..3875179 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T262346 WP_003102740.1 NZ_CP109920:3869877-3870455 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT262346 WP_003088112.1 NZ_CP109920:3869234-3869788 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References