262345

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2734282..2735324 Replicon chromosome
Accession NZ_CP109920
Organism Pseudomonas aeruginosa strain PALA39

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PALA39_RS13000 Protein ID WP_003109777.1
Coordinates 2734749..2735324 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PALA39_RS12995 Protein ID WP_003050245.1
Coordinates 2734282..2734752 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA39_RS12960 (PALA39_02571) 2729674..2731092 - 1419 WP_003109776.1 TIGR03752 family integrating conjugative element protein -
PALA39_RS12965 (PALA39_02572) 2731082..2731993 - 912 WP_003105643.1 TIGR03749 family integrating conjugative element protein -
PALA39_RS12970 (PALA39_02573) 2731990..2732682 - 693 WP_003105641.1 TIGR03746 family integrating conjugative element protein -
PALA39_RS12975 (PALA39_02574) 2732679..2733077 - 399 WP_003105639.1 TIGR03750 family conjugal transfer protein -
PALA39_RS12980 (PALA39_02575) 2733089..2733448 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
PALA39_RS12985 (PALA39_02576) 2733465..2733698 - 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
PALA39_RS12990 (PALA39_02577) 2733695..2734078 - 384 WP_003105635.1 RAQPRD family integrative conjugative element protein -
PALA39_RS12995 (PALA39_02578) 2734282..2734752 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PALA39_RS13000 (PALA39_02579) 2734749..2735324 + 576 WP_003109777.1 PIN domain-containing protein Toxin
PALA39_RS13005 (PALA39_02580) 2735342..2736256 + 915 WP_003105629.1 AAA family ATPase -
PALA39_RS13010 (PALA39_02581) 2736253..2736723 + 471 WP_003105626.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
PALA39_RS13015 (PALA39_02582) 2736720..2737220 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
PALA39_RS13020 (PALA39_02583) 2737220..2738122 + 903 WP_003105624.1 CBASS oligonucleotide cyclase -
PALA39_RS13025 (PALA39_02584) 2738161..2738886 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2679303..2784131 104828


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21644.79 Da        Isoelectric Point: 5.6172

>T262345 WP_003109777.1 NZ_CP109920:2734749-2735324 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT262345 WP_003050245.1 NZ_CP109920:2734282-2734752 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References