Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 2488784..2489337 Replicon chromosome
Accession NZ_CP109920
Organism Pseudomonas aeruginosa strain PALA39

Toxin (Protein)


Gene name parE Uniprot ID Q88JZ3
Locus tag PALA39_RS11890 Protein ID WP_010953434.1
Coordinates 2489044..2489337 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q88JZ4
Locus tag PALA39_RS11885 Protein ID WP_010953433.1
Coordinates 2488784..2489056 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA39_RS11855 (PALA39_02356) 2484356..2484715 - 360 Protein_2340 DNA repair protein RadC -
PALA39_RS11860 (PALA39_02357) 2484687..2485637 - 951 WP_031299400.1 hypothetical protein -
PALA39_RS11865 (PALA39_02358) 2485730..2486734 - 1005 WP_010953429.1 YqaJ viral recombinase family protein -
PALA39_RS11870 (PALA39_02359) 2486814..2487782 - 969 WP_031299399.1 DUF932 domain-containing protein -
PALA39_RS11875 (PALA39_02360) 2487880..2488209 - 330 WP_010953431.1 hypothetical protein -
PALA39_RS11880 (PALA39_02361) 2488414..2488659 + 246 WP_010953432.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
PALA39_RS11885 (PALA39_02362) 2488784..2489056 + 273 WP_010953433.1 CopG family ribbon-helix-helix protein Antitoxin
PALA39_RS11890 2489044..2489337 + 294 WP_010953434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA39_RS11895 (PALA39_02363) 2489331..2490740 - 1410 WP_010953435.1 site-specific integrase -
PALA39_RS11900 (PALA39_02364) 2491178..2493958 + 2781 WP_023464835.1 type I restriction-modification enzyme R subunit C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2460809..2511806 50997


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11155.61 Da        Isoelectric Point: 5.9081

>T262344 WP_010953434.1 NZ_CP109920:2489044-2489337 [Pseudomonas aeruginosa]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10373.53 Da        Isoelectric Point: 5.5744

>AT262344 WP_010953433.1 NZ_CP109920:2488784-2489056 [Pseudomonas aeruginosa]
MATSIKIDDDLKGRIQHLACLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGQHLTGQEARTWLGSWGTD
AEAELPKCHD

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W5CNE8

Antitoxin

Source ID Structure
AlphaFold DB Q88JZ4

References