Detailed information of TA system TA026234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 2112649..2113190
• Replicon: chromosome
• Accession: NC_017059
• Organism: Rhodospirillum photometricum DSM 122

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: H6SK65
• Locus tag: RSPPHO_RS09430
• Protein ID: WP_014415016.1
• Coordinates: 2112867..2113190 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: RSPPHO_RS09425
• Protein ID: WP_041794943.1
• Coordinates: 2112649..2112870 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RSPPHO_RS09405	2108405..2108662	+	258	WP_051013786.1	hypothetical protein	-
RSPPHO_RS09410	2108721..2110544	-	1824	WP_041794939.1	glutamine--fructose-6-phosphate transaminase (isomerizing)	-
RSPPHO_RS09415	2110719..2111831	-	1113	WP_041794941.1	RNA methyltransferase	-
RSPPHO_RS09420	2112086..2112415	+	330	WP_014415014.1	multidrug efflux SMR transporter	-
RSPPHO_RS09425	2112649..2112870	+	222	WP_041794943.1	antitoxin MazE family protein	Antitoxin
RSPPHO_RS09430	2112867..2113190	+	324	WP_014415016.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
RSPPHO_RS19875	2113248..2114603	-	1356	WP_157879160.1	hypothetical protein	-
RSPPHO_RS09440	2114955..2115251	-	297	WP_014415017.1	ETC complex I subunit	-
RSPPHO_RS09450	2115661..2116041	-	381	WP_014415018.1	hypothetical protein	-
RSPPHO_RS20540	2116235..2116492	+	258	WP_014415019.1	energy transducer TonB	-
RSPPHO_RS09460	2116699..2117277	+	579	WP_197535651.1	MotA/TolQ/ExbB proton channel family protein	-
RSPPHO_RS09465	2117274..2117693	+	420	WP_041797033.1	biopolymer transporter ExbD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-103)

Antitoxin

• Antitoxin MazE-like (7-71)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11430.51 Da
• Isoelectric Point: 10.1834

>T26234 WP_014415016.1 NC_017059:2112867-2113190 [Pararhodospirillum photometricum DSM 122]
VKRGDLVTIALQGDFGKPRPALIIQSDQFHQSATRAVLLLTGTLVDAPLIRLMLDPTPENGLLKPSQIMIDKPMTVPVTK
IGPGFGRVDDGTLLAVNRALAVFLGFA

Nucleotide

• Length: 324 bp

>T26234 NC_017059:2112867-2113190 [Pararhodospirillum photometricum DSM 122]
GTGAAGCGCGGGGATCTGGTCACGATTGCCCTGCAAGGGGACTTCGGAAAGCCACGCCCCGCTCTGATTATCCAGTCCGA
CCAATTCCACCAGAGCGCCACCCGCGCGGTCCTTTTGCTGACCGGCACCCTGGTTGACGCACCTCTGATCCGGCTGATGC
TCGACCCGACACCGGAAAACGGGCTGTTGAAGCCTTCTCAAATCATGATCGACAAGCCGATGACGGTCCCCGTGACAAAG
ATCGGCCCGGGGTTCGGACGGGTCGATGACGGGACCTTGCTCGCTGTCAACCGAGCTCTGGCGGTATTCCTGGGGTTTGC
CTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8179.25 Da
• Isoelectric Point: 8.0290

>AT26234 WP_041794943.1 NC_017059:2112649-2112870 [Pararhodospirillum photometricum DSM 122]
MSSSVTRRVSKHRAGLRAAGMRPIQIWVPDTRRPGFAEECRRQSALTAESDAADKDLQDFMEAALAKMEGWTE

Nucleotide

• Length: 222 bp

>AT26234 NC_017059:2112649-2112870 [Pararhodospirillum photometricum DSM 122]
ATGTCATCGAGCGTGACGAGGCGGGTGAGCAAGCATCGAGCAGGCCTGCGGGCTGCCGGGATGCGCCCGATTCAGATTTG
GGTACCCGACACCCGGCGCCCCGGCTTTGCCGAGGAATGCCGCCGGCAATCGGCCCTGACTGCCGAAAGCGATGCCGCCG
ACAAAGACCTGCAAGACTTCATGGAGGCCGCACTTGCGAAGATGGAGGGCTGGACAGAGTGA

Structures

Toxin

• AlphaFold DB: H6SK65