Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4431345..4432603 Replicon chromosome
Accession NZ_CP109919
Organism Pseudomonas aeruginosa strain PALA56

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA56_RS20635 Protein ID WP_003163133.1
Coordinates 4431345..4432100 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA56_RS20640 Protein ID WP_003086329.1
Coordinates 4432235..4432603 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA56_RS20625 (PALA56_04107) 4426517..4429060 + 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -
PALA56_RS20630 (PALA56_04108) 4429215..4430576 - 1362 WP_079262974.1 DNA recombination protein RmuC -
PALA56_RS20635 (PALA56_04109) 4431345..4432100 - 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
PALA56_RS20640 (PALA56_04110) 4432235..4432603 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA56_RS20645 (PALA56_04111) 4432676..4433962 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
PALA56_RS20650 (PALA56_04112) 4434018..4435607 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PALA56_RS20655 (PALA56_04113) 4435686..4436162 + 477 WP_003112531.1 hypothetical protein -
PALA56_RS20660 4436165..4436440 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T262339 WP_003163133.1 NZ_CP109919:c4432100-4431345 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT262339 WP_003086329.1 NZ_CP109919:c4432603-4432235 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References