Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3500862..3502083 Replicon chromosome
Accession NZ_CP109919
Organism Pseudomonas aeruginosa strain PALA56

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PALA56_RS16240 Protein ID WP_003102740.1
Coordinates 3501505..3502083 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA56_RS16235 Protein ID WP_003088112.1
Coordinates 3500862..3501416 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA56_RS16210 (PALA56_03224) 3496430..3496981 + 552 WP_003132721.1 XRE family transcriptional regulator -
PALA56_RS16215 (PALA56_03225) 3496978..3497376 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PALA56_RS16220 (PALA56_03226) 3497389..3497712 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA56_RS16225 (PALA56_03227) 3498043..3498504 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA56_RS16230 (PALA56_03228) 3498509..3500704 + 2196 WP_014603034.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA56_RS16235 (PALA56_03229) 3500862..3501416 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA56_RS16240 (PALA56_03230) 3501505..3502083 + 579 WP_003102740.1 HD domain-containing protein Toxin
PALA56_RS16245 (PALA56_03231) 3502191..3503378 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA56_RS16250 (PALA56_03232) 3503368..3505539 - 2172 WP_014603035.1 type I secretion system permease/ATPase -
PALA56_RS16255 (PALA56_03233) 3505529..3506806 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T262338 WP_003102740.1 NZ_CP109919:3501505-3502083 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT262338 WP_003088112.1 NZ_CP109919:3500862-3501416 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References