Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4913680..4914288 Replicon chromosome
Accession NZ_CP109918
Organism Pseudomonas aeruginosa strain PALA55

Toxin (Protein)


Gene name PfiT Uniprot ID A0A444LUU5
Locus tag PALA55_RS22920 Protein ID WP_019486378.1
Coordinates 4913680..4914027 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag PALA55_RS22925 Protein ID WP_003114155.1
Coordinates 4914037..4914288 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA55_RS22890 (PALA55_04528) 4909041..4909313 + 273 WP_003120794.1 cysteine-rich CWC family protein -
PALA55_RS22895 (PALA55_04529) 4909313..4910005 + 693 WP_003098362.1 16S rRNA pseudouridine(516) synthase -
PALA55_RS22900 (PALA55_04530) 4910141..4911184 + 1044 WP_003098363.1 L,D-transpeptidase -
PALA55_RS22905 (PALA55_04531) 4911264..4912001 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
PALA55_RS22910 (PALA55_04532) 4912453..4913355 + 903 WP_003098365.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
PALA55_RS22920 (PALA55_04534) 4913680..4914027 - 348 WP_019486378.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA55_RS22925 4914037..4914288 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PALA55_RS22930 (PALA55_04535) 4914502..4915485 - 984 WP_019682343.1 tyrosine-type recombinase/integrase -
PALA55_RS22935 (PALA55_04536) 4915485..4916777 - 1293 WP_023088869.1 hypothetical protein -
PALA55_RS22940 (PALA55_04538) 4917007..4918281 - 1275 WP_109392597.1 zonular occludens toxin family protein -
PALA55_RS22945 (PALA55_04539) 4918285..4918641 - 357 WP_003114150.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 4913680..4935824 22144


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12956.72 Da        Isoelectric Point: 4.4212

>T262334 WP_019486378.1 NZ_CP109918:c4914027-4913680 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT262334 WP_003114155.1 NZ_CP109918:c4914288-4914037 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444LUU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References