262333

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4431342..4432600 Replicon chromosome
Accession NZ_CP109918
Organism Pseudomonas aeruginosa strain PALA55

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag PALA55_RS20560 Protein ID WP_003112528.1
Coordinates 4431342..4432097 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA55_RS20565 Protein ID WP_003086329.1
Coordinates 4432232..4432600 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA55_RS20550 (PALA55_04072) 4426515..4429058 + 2544 WP_250177674.1 acyl-homoserine-lactone acylase QuiP -
PALA55_RS20555 (PALA55_04073) 4429213..4430574 - 1362 WP_003134034.1 DNA recombination protein RmuC -
PALA55_RS20560 (PALA55_04074) 4431342..4432097 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
PALA55_RS20565 (PALA55_04075) 4432232..4432600 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA55_RS20570 (PALA55_04076) 4432673..4433959 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
PALA55_RS20575 (PALA55_04077) 4434015..4435604 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PALA55_RS20580 (PALA55_04078) 4435683..4436159 + 477 WP_003112531.1 hypothetical protein -
PALA55_RS20585 4436162..4436437 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T262333 WP_003112528.1 NZ_CP109918:c4432097-4431342 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT262333 WP_003086329.1 NZ_CP109918:c4432600-4432232 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References