Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3512795..3514015 | Replicon | chromosome |
| Accession | NZ_CP109918 | ||
| Organism | Pseudomonas aeruginosa strain PALA55 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | PALA55_RS16250 | Protein ID | WP_003160088.1 |
| Coordinates | 3513437..3514015 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | PALA55_RS16245 | Protein ID | WP_003088112.1 |
| Coordinates | 3512795..3513349 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PALA55_RS16220 (PALA55_03205) | 3508363..3508914 | + | 552 | WP_003132721.1 | XRE family transcriptional regulator | - |
| PALA55_RS16225 (PALA55_03206) | 3508911..3509309 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| PALA55_RS16230 (PALA55_03207) | 3509322..3509645 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| PALA55_RS16235 (PALA55_03208) | 3509976..3510437 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| PALA55_RS16240 (PALA55_03209) | 3510442..3512637 | + | 2196 | WP_003122807.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| PALA55_RS16245 (PALA55_03210) | 3512795..3513349 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| PALA55_RS16250 (PALA55_03211) | 3513437..3514015 | + | 579 | WP_003160088.1 | HD domain-containing protein | Toxin |
| PALA55_RS16255 (PALA55_03212) | 3514124..3515311 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| PALA55_RS16260 (PALA55_03213) | 3515301..3517472 | - | 2172 | WP_009876279.1 | type I secretion system permease/ATPase | - |
| PALA55_RS16265 (PALA55_03214) | 3517462..3518739 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21816.65 Da Isoelectric Point: 5.1625
>T262332 WP_003160088.1 NZ_CP109918:3513437-3514015 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT262332 WP_003088112.1 NZ_CP109918:3512795-3513349 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|