Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1863271..1864779 Replicon chromosome
Accession NZ_CP109918
Organism Pseudomonas aeruginosa strain PALA55

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag PALA55_RS08750 Protein ID WP_003119682.1
Coordinates 1863271..1863858 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag PALA55_RS08755 Protein ID WP_003091607.1
Coordinates 1863925..1864779 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA55_RS08745 1859526..1863005 - 3480 Protein_1734 PAS domain-containing hybrid sensor histidine kinase/response regulator -
PALA55_RS08750 (PALA55_01734) 1863271..1863858 + 588 WP_003119682.1 GNAT family protein Toxin
PALA55_RS08755 (PALA55_01735) 1863925..1864779 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
PALA55_RS08760 (PALA55_01736) 1864876..1867041 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
PALA55_RS08765 (PALA55_01737) 1867216..1869090 + 1875 WP_250177554.1 MFS transporter -
PALA55_RS08770 (PALA55_01738) 1869151..1869360 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T262331 WP_003119682.1 NZ_CP109918:1863271-1863858 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT262331 WP_003091607.1 NZ_CP109918:1863925-1864779 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References