Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 146801..147306 Replicon chromosome
Accession NZ_CP109918
Organism Pseudomonas aeruginosa strain PALA55

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PALA55_RS00685 Protein ID WP_003083773.1
Coordinates 146801..147082 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PALA55_RS00690 Protein ID WP_003083775.1
Coordinates 147079..147306 (-) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA55_RS00660 (PALA55_00126) 142052..143401 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
PALA55_RS00665 (PALA55_00127) 143450..144136 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PALA55_RS00670 (PALA55_00128) 144237..144971 + 735 WP_003115036.1 GntR family transcriptional regulator -
PALA55_RS00675 (PALA55_00129) 145151..145561 + 411 WP_003101225.1 aegerolysin family protein -
PALA55_RS00680 (PALA55_00130) 145593..146501 - 909 WP_003083769.1 LysR family transcriptional regulator -
PALA55_RS00685 (PALA55_00131) 146801..147082 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PALA55_RS00690 (PALA55_00132) 147079..147306 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PALA55_RS00695 (PALA55_00133) 147482..148102 - 621 WP_003101226.1 hypothetical protein -
PALA55_RS00700 (PALA55_00134) 148203..148703 + 501 WP_003101228.1 LEA type 2 family protein -
PALA55_RS00705 (PALA55_00135) 148776..149117 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA55_RS00710 (PALA55_00136) 149199..150626 - 1428 WP_003083784.1 GABA permease -
PALA55_RS00715 (PALA55_00137) 150795..152288 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T262330 WP_003083773.1 NZ_CP109918:c147082-146801 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp


Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT262330 WP_003083775.1 NZ_CP109918:c147306-147079 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6XRW


Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References