Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 794..1313 Replicon plasmid pASal1_J227
Accession NZ_CP109911
Organism Aeromonas salmonicida subsp. salmonicida strain J227

Toxin (Protein)


Gene name relE Uniprot ID Q7X2F1
Locus tag AXW80_RS23320 Protein ID WP_005321942.1
Coordinates 1026..1313 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q8GMP0
Locus tag AXW80_RS23315 Protein ID WP_011069626.1
Coordinates 794..1036 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXW80_RS23305 (AXW80_23235) 107..313 + 207 WP_129712442.1 hypothetical protein -
AXW80_RS23310 (AXW80_23240) 430..762 + 333 WP_005321955.1 hypothetical protein -
AXW80_RS23315 (AXW80_23245) 794..1036 + 243 WP_011069626.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AXW80_RS23320 (AXW80_23250) 1026..1313 + 288 WP_005321942.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AXW80_RS23325 (AXW80_23255) 1497..2504 + 1008 WP_005321944.1 replication initiation protein -
AXW80_RS23330 (AXW80_23260) 3152..3562 + 411 WP_011116719.1 MobC family plasmid mobilization relaxosome protein -
AXW80_RS23335 (AXW80_23265) 3612..4229 + 618 Protein_7 relaxase/mobilization nuclease domain-containing protein -
AXW80_RS23340 (AXW80_23270) 4267..4800 + 534 WP_011069625.1 hypothetical protein -
AXW80_RS23345 (AXW80_23275) 4801..5142 + 342 WP_011116720.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..5430 5430


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-61)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11356.17 Da        Isoelectric Point: 9.9149

>T262329 WP_005321942.1 NZ_CP109911:1026-1313 [Aeromonas salmonicida subsp. salmonicida]
MTFELEFDPRAWKEWKKLGDTVRQQFKKKLAEVLERPRVEANRLHGLPDCYKIKLRGAGYRLVYQVQDDRVLVFVVAVGK
REREQVYLDAGYRLE

Download         Length: 288 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9127.47 Da        Isoelectric Point: 4.6151

>AT262329 WP_011069626.1 NZ_CP109911:794-1036 [Aeromonas salmonicida subsp. salmonicida]
MGTINLRIDDELKTRSYAVLERLGVTPSELLRQTLEYVASQERLPFRTTVVTEDEEALLVLVRERLASPQKGIRVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151KDX2

Antitoxin

Source ID Structure
AlphaFold DB Q8GMP0

References