Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2512706..2513317 Replicon chromosome
Accession NZ_CP109897
Organism Xylella fastidiosa subsp. fastidiosa strain XYL461

Toxin (Protein)


Gene name relE Uniprot ID Q879T9
Locus tag OK116_RS11535 Protein ID WP_011098375.1
Coordinates 2513018..2513317 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag OK116_RS11530 Protein ID WP_004085003.1
Coordinates 2512706..2513014 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK116_RS11495 (OK116_11475) 2509276..2510037 - 762 WP_004090267.1 Bax inhibitor-1/YccA family protein -
OK116_RS11520 (OK116_11500) 2511376..2511786 - 411 WP_228446157.1 hypothetical protein -
OK116_RS11525 (OK116_11505) 2511775..2512632 + 858 WP_228446158.1 hypothetical protein -
OK116_RS11530 (OK116_11510) 2512706..2513014 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
OK116_RS11535 (OK116_11515) 2513018..2513317 - 300 WP_011098375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OK116_RS11540 (OK116_11520) 2513405..2513950 + 546 WP_011098376.1 hypothetical protein -
OK116_RS11545 (OK116_11525) 2513962..2514105 + 144 WP_155115087.1 hypothetical protein -
OK116_RS11550 (OK116_11530) 2514258..2514638 - 381 WP_004089371.1 DUF596 domain-containing protein -
OK116_RS11555 (OK116_11535) 2514643..2515773 - 1131 WP_012382788.1 DUF769 domain-containing protein -
OK116_RS11560 (OK116_11540) 2516081..2516461 - 381 WP_004087391.1 DUF596 domain-containing protein -
OK116_RS11565 (OK116_11545) 2516473..2517834 - 1362 WP_012382789.1 DUF637 domain-containing protein -
OK116_RS11570 (OK116_11550) 2517914..2518057 + 144 WP_155115088.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2463489..2513767 50278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11378.17 Da        Isoelectric Point: 10.3861

>T262326 WP_011098375.1 NZ_CP109897:c2513317-2513018 [Xylella fastidiosa subsp. fastidiosa]
MTYTLKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT262326 WP_004085003.1 NZ_CP109897:c2513014-2512706 [Xylella fastidiosa subsp. fastidiosa]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q879T9

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References