Detailed information of TA system TA026232

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 1737269..1737966
• Replicon: chromosome
• Accession: NC_017059
• Organism: Rhodospirillum photometricum DSM 122

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: H6SJA1
• Locus tag: RSPPHO_RS07685
• Protein ID: WP_014414705.1
• Coordinates: 1737269..1737694 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: RSPPHO_RS07690
• Protein ID: WP_081581683.1
• Coordinates: 1737691..1737966 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RSPPHO_RS07665	1733897..1734196	-	300	WP_014414704.1	putative addiction module antidote protein	-
RSPPHO_RS07670	1734200..1734496	-	297	WP_041796867.1	type II toxin-antitoxin system RelE/ParE family toxin	-
RSPPHO_RS19820	1734664..1735305	-	642	WP_157879136.1	hypothetical protein	-
RSPPHO_RS18840	1735298..1736380	-	1083	WP_081581682.1	DUF262 domain-containing protein	-
RSPPHO_RS07685	1737269..1737694	-	426	WP_014414705.1	type II toxin-antitoxin system VapC family toxin	Toxin
RSPPHO_RS07690	1737691..1737966	-	276	WP_081581683.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
RSPPHO_RS07695	1738243..1738668	+	426	WP_014414707.1	hypothetical protein	-
RSPPHO_RS07700	1738690..1739307	+	618	WP_041794735.1	leucine-rich repeat domain-containing protein	-
RSPPHO_RS07705	1739392..1740477	-	1086	WP_014414708.1	S-methyl-5-thioribose-1-phosphate isomerase	-
RSPPHO_RS07710	1740559..1741446	-	888	WP_041796869.1	S-methyl-5'-thioadenosine phosphorylase	-
RSPPHO_RS07715	1741613..1741981	-	369	WP_081581841.1	metalloregulator ArsR/SmtB family transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-71)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15676.95 Da
• Isoelectric Point: 5.5896

>T26232 WP_014414705.1 NC_017059:c1737694-1737269 [Pararhodospirillum photometricum DSM 122]
VSYLLDTNVVSEWVNPRPDPGVVRWLAEIDEDRVFLSVITLAELRHGLDRMPEGARRHRLDGWLTTDLPLRFEGRLLPID
GAVADTWGKIMARAQAGGRPMGPMDAFVAATAEIHHLTLVTRNASDFIVLGQTIVNPWSQA

Nucleotide

• Length: 426 bp

>T26232 NC_017059:c1737694-1737269 [Pararhodospirillum photometricum DSM 122]
GTGAGCTACTTGCTCGATACCAACGTCGTCTCGGAATGGGTCAACCCCCGCCCCGACCCCGGGGTGGTGCGATGGCTGGC
CGAGATCGACGAGGACCGGGTGTTCCTCAGCGTCATCACCCTGGCCGAACTGCGCCACGGACTCGACCGGATGCCGGAGG
GAGCGCGGCGCCACCGCCTCGACGGCTGGCTGACCACCGACCTTCCCCTTCGTTTCGAAGGAAGGCTGCTGCCGATCGAC
GGCGCGGTGGCTGATACCTGGGGAAAAATCATGGCCCGCGCCCAGGCCGGGGGCCGGCCGATGGGGCCGATGGACGCGTT
CGTCGCGGCGACCGCCGAGATTCACCACCTCACCCTGGTCACCCGCAACGCGTCAGACTTCATCGTCCTGGGACAGACGA
TCGTCAATCCTTGGAGCCAAGCCTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10156.36 Da
• Isoelectric Point: 5.8788

>AT26232 WP_081581683.1 NC_017059:c1737966-1737691 [Pararhodospirillum photometricum DSM 122]
MSLPRETAPMGTWTVAEAKAKFSEVIEQARQGTPQTITRNGRSAAVVVSVEEWDRKTRRSGTLAEFFAESPLHGSELTVE
RRQDGPREIDL

Nucleotide

• Length: 276 bp

>AT26232 NC_017059:c1737966-1737691 [Pararhodospirillum photometricum DSM 122]
ATGTCTTTGCCTCGGGAGACCGCGCCGATGGGAACCTGGACCGTCGCCGAAGCGAAAGCCAAATTCAGCGAAGTGATTGA
GCAGGCCCGGCAGGGTACACCGCAGACCATCACCCGCAACGGGCGCAGCGCCGCCGTGGTGGTGTCGGTCGAGGAGTGGG
ACCGCAAGACCCGGCGCTCCGGCACTCTGGCCGAATTCTTCGCCGAATCCCCACTGCACGGGTCGGAACTGACCGTGGAA
CGCCGCCAGGACGGCCCACGCGAAATCGACCTGTGA

Structures

Toxin

• AlphaFold DB: H6SJA1