Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2506858..2507469 Replicon chromosome
Accession NZ_CP109894
Organism Xylella fastidiosa subsp. fastidiosa strain CFBP8351

Toxin (Protein)


Gene name relE Uniprot ID Q879T9
Locus tag OK118_RS11315 Protein ID WP_011098375.1
Coordinates 2507170..2507469 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag OK118_RS11310 Protein ID WP_004085003.1
Coordinates 2506858..2507166 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK118_RS11275 (OK118_11270) 2503428..2504189 - 762 WP_004090267.1 Bax inhibitor-1/YccA family protein -
OK118_RS11300 (OK118_11295) 2505528..2505938 - 411 WP_228446157.1 hypothetical protein -
OK118_RS11305 (OK118_11300) 2505927..2506784 + 858 WP_228446158.1 hypothetical protein -
OK118_RS11310 (OK118_11305) 2506858..2507166 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
OK118_RS11315 (OK118_11310) 2507170..2507469 - 300 WP_011098375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OK118_RS11320 (OK118_11315) 2507557..2508102 + 546 WP_011098376.1 hypothetical protein -
OK118_RS11325 (OK118_11320) 2508114..2508257 + 144 WP_155115087.1 hypothetical protein -
OK118_RS11330 (OK118_11325) 2508410..2508790 - 381 WP_004089371.1 DUF596 domain-containing protein -
OK118_RS11335 (OK118_11330) 2508795..2509925 - 1131 WP_012382788.1 DUF769 domain-containing protein -
OK118_RS11340 (OK118_11335) 2510233..2510613 - 381 WP_004087391.1 DUF596 domain-containing protein -
OK118_RS11345 (OK118_11340) 2510625..2511986 - 1362 WP_012382789.1 DUF637 domain-containing protein -
OK118_RS11350 (OK118_11345) 2512066..2512209 + 144 WP_155115088.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2460326..2507919 47593


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11378.17 Da        Isoelectric Point: 10.3861

>T262317 WP_011098375.1 NZ_CP109894:c2507469-2507170 [Xylella fastidiosa subsp. fastidiosa]
MTYTLKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT262317 WP_004085003.1 NZ_CP109894:c2507166-2506858 [Xylella fastidiosa subsp. fastidiosa]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q879T9

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References