Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2487618..2488229 Replicon chromosome
Accession NZ_CP109891
Organism Xylella fastidiosa subsp. fastidiosa strain CFBP8083

Toxin (Protein)


Gene name relE Uniprot ID Q879T9
Locus tag OK113_RS11115 Protein ID WP_011098375.1
Coordinates 2487930..2488229 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag OK113_RS11110 Protein ID WP_004085003.1
Coordinates 2487618..2487926 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK113_RS11080 (OK113_11080) 2484188..2484949 - 762 WP_004090267.1 Bax inhibitor-1/YccA family protein -
OK113_RS11105 (OK113_11105) 2486141..2487544 + 1404 WP_011098374.1 hypothetical protein -
OK113_RS11110 (OK113_11110) 2487618..2487926 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
OK113_RS11115 (OK113_11115) 2487930..2488229 - 300 WP_011098375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OK113_RS11120 (OK113_11120) 2488317..2488850 + 534 WP_225621759.1 hypothetical protein -
OK113_RS11125 (OK113_11125) 2488873..2489016 + 144 WP_155115087.1 hypothetical protein -
OK113_RS11130 (OK113_11130) 2489169..2489549 - 381 WP_004089371.1 DUF596 domain-containing protein -
OK113_RS11135 (OK113_11135) 2489554..2490684 - 1131 WP_012382788.1 DUF769 domain-containing protein -
OK113_RS11140 (OK113_11140) 2490992..2491372 - 381 WP_004087391.1 DUF596 domain-containing protein -
OK113_RS11145 (OK113_11145) 2491384..2492745 - 1362 WP_012382789.1 DUF637 domain-containing protein -
OK113_RS11150 (OK113_11150) 2492825..2492968 + 144 WP_155115088.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2438426..2494494 56068


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11378.17 Da        Isoelectric Point: 10.3861

>T262308 WP_011098375.1 NZ_CP109891:c2488229-2487930 [Xylella fastidiosa subsp. fastidiosa]
MTYTLKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT262308 WP_004085003.1 NZ_CP109891:c2487926-2487618 [Xylella fastidiosa subsp. fastidiosa]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q879T9

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References