Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2486512..2487123 Replicon chromosome
Accession NZ_CP109890
Organism Xylella fastidiosa subsp. fastidiosa strain WM1-1

Toxin (Protein)


Gene name relE Uniprot ID Q879T9
Locus tag OK119_RS11160 Protein ID WP_011098375.1
Coordinates 2486824..2487123 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag OK119_RS11155 Protein ID WP_004085003.1
Coordinates 2486512..2486820 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK119_RS11125 (OK119_11120) 2483082..2483843 - 762 WP_004090267.1 Bax inhibitor-1/YccA family protein -
OK119_RS11150 (OK119_11145) 2485035..2486438 + 1404 WP_011098374.1 hypothetical protein -
OK119_RS11155 (OK119_11150) 2486512..2486820 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
OK119_RS11160 (OK119_11155) 2486824..2487123 - 300 WP_011098375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OK119_RS11165 (OK119_11160) 2487211..2487744 + 534 WP_225621759.1 hypothetical protein -
OK119_RS11170 (OK119_11165) 2487767..2487910 + 144 WP_155115087.1 hypothetical protein -
OK119_RS11175 (OK119_11170) 2488063..2488443 - 381 WP_004089371.1 DUF596 domain-containing protein -
OK119_RS11180 (OK119_11175) 2488448..2489578 - 1131 WP_012382788.1 DUF769 domain-containing protein -
OK119_RS11185 (OK119_11180) 2489886..2490266 - 381 WP_004087391.1 DUF596 domain-containing protein -
OK119_RS11190 (OK119_11185) 2490278..2491639 - 1362 WP_012382789.1 DUF637 domain-containing protein -
OK119_RS11195 (OK119_11190) 2491719..2491862 + 144 WP_155115088.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2437272..2487573 50301


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11378.17 Da        Isoelectric Point: 10.3861

>T262299 WP_011098375.1 NZ_CP109890:c2487123-2486824 [Xylella fastidiosa subsp. fastidiosa]
MTYTLKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT262299 WP_004085003.1 NZ_CP109890:c2486820-2486512 [Xylella fastidiosa subsp. fastidiosa]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q879T9

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References