Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 724769..725305 Replicon chromosome
Accession NC_017058
Organism Rickettsia australis str. Cutlack

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MC5_RS03765 Protein ID WP_014412663.1
Coordinates 725129..725305 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H8K792
Locus tag MC5_RS03760 Protein ID WP_014412662.1
Coordinates 724769..725020 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MC5_RS03735 720721..721362 + 642 WP_025999564.1 LysE/ArgO family amino acid transporter -
MC5_RS03740 721340..722014 + 675 WP_014412658.1 uroporphyrinogen-III synthase -
MC5_RS03745 721998..722690 + 693 WP_014412659.1 hypothetical protein -
MC5_RS03750 722683..723687 + 1005 WP_014412660.1 hypothetical protein -
MC5_RS03755 723902..724621 - 720 WP_014412661.1 alpha/beta hydrolase -
MC5_RS03760 724769..725020 + 252 WP_014412662.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MC5_RS03765 725129..725305 + 177 WP_014412663.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
MC5_RS03770 725340..725780 - 441 WP_014412664.1 host attachment protein -
MC5_RS03775 725843..726568 - 726 WP_014412665.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
MC5_RS03780 726645..727637 + 993 WP_014412666.1 tryptophan--tRNA ligase -
MC5_RS03790 728840..729745 - 906 WP_014412668.1 hydroxymethylbilane synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-47)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 7103.42 Da        Isoelectric Point: 8.0702

>T26229 WP_014412663.1 NC_017058:725129-725305 [Rickettsia australis str. Cutlack]
MLVNNIALPQKYRPHKLIGNHYPKWECHIEPDWLLIYEIKKIQLFYIAQEHMQIFLSP

Download         Length: 177 bp

>T26229 NC_017058:725129-725305 [Rickettsia australis str. Cutlack]
ATGCTTGTAAACAATATTGCTTTACCACAAAAATATAGACCTCATAAACTCATAGGCAACCATTACCCAAAATGGGAATG
TCATATTGAACCTGATTGGCTATTAATATATGAAATAAAAAAGATACAATTATTTTATATCGCACAGGAACATATGCAGA
TTTTTTTAAGTCCATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9584.01 Da        Isoelectric Point: 5.1067

>AT26229 WP_014412662.1 NC_017058:724769-725020 [Rickettsia australis str. Cutlack]
MENTVDIRIRVSADIKIEAEEIFKQMGMTMSEAMRIFLNQCINSGGLPFKPHIKIPNKETLESFKQAENGEFESYNLNNL
KNF

Download         Length: 252 bp

>AT26229 NC_017058:724769-725020 [Rickettsia australis str. Cutlack]
ATGGAGAATACAGTAGATATTAGAATACGTGTGTCAGCAGATATAAAGATAGAAGCAGAAGAAATATTTAAGCAAATGGG
GATGACTATGTCGGAAGCCATGAGGATCTTCCTAAATCAATGTATAAATAGCGGCGGTTTGCCTTTCAAACCACATATTA
AGATTCCTAATAAAGAAACATTAGAATCATTTAAGCAAGCAGAAAACGGTGAATTTGAAAGCTATAATTTAAACAATTTG
AAAAATTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB H8K792

References