Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2638164..2638775 Replicon chromosome
Accession NZ_CP109886
Organism Xylella fastidiosa subsp. fastidiosa strain CFBP8073

Toxin (Protein)


Gene name relE Uniprot ID A0A060HHU8
Locus tag OK117_RS12075 Protein ID WP_024749166.1
Coordinates 2638476..2638775 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag OK117_RS12070 Protein ID WP_004085003.1
Coordinates 2638164..2638472 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK117_RS12040 (OK117_12050) 2634743..2635504 - 762 WP_004090267.1 Bax inhibitor-1/YccA family protein -
OK117_RS12065 (OK117_12075) 2636696..2638090 + 1395 WP_272142406.1 hypothetical protein -
OK117_RS12070 (OK117_12080) 2638164..2638472 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
OK117_RS12075 (OK117_12085) 2638476..2638775 - 300 WP_024749166.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OK117_RS12080 (OK117_12090) 2638863..2639405 + 543 WP_272142416.1 hypothetical protein -
OK117_RS12085 (OK117_12095) 2639417..2639560 + 144 WP_200904642.1 hypothetical protein -
OK117_RS12090 (OK117_12100) 2639726..2640121 - 396 Protein_2358 DUF596 domain-containing protein -
OK117_RS12095 (OK117_12105) 2640126..2641487 - 1362 WP_272142420.1 DUF769 domain-containing protein -
OK117_RS12100 (OK117_12110) 2641567..2641710 + 144 WP_272142424.1 hypothetical protein -
OK117_RS12105 (OK117_12115) 2641863..2642239 - 377 Protein_2361 DUF596 domain-containing protein -
OK117_RS12110 (OK117_12120) 2642244..2642600 - 357 WP_058565148.1 DUF769 domain-containing protein -
OK117_RS12115 (OK117_12125) 2642815..2643201 - 387 WP_058565149.1 DUF596 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11364.14 Da        Isoelectric Point: 10.3861

>T262286 WP_024749166.1 NZ_CP109886:c2638775-2638476 [Xylella fastidiosa subsp. fastidiosa]
MTYTVKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT262286 WP_004085003.1 NZ_CP109886:c2638472-2638164 [Xylella fastidiosa subsp. fastidiosa]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HHU8

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References