Detailed information of TA system TA026228

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 19994..20519
• Replicon: plasmid p798_93
• Accession: NC_017054
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium str. 798

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: UMN798_RS23725
• Protein ID: WP_001159863.1
• Coordinates: 20214..20519 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: UMN798_RS23720
• Protein ID: WP_000813641.1
• Coordinates: 19994..20212 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UMN798_RS23695	15281..15662	+	382	Protein_19	YgiW/YdeI family stress tolerance OB fold protein	-
UMN798_RS26475	15831..16275	+	445	Protein_20	site-specific integrase	-
UMN798_RS23705	16534..17523	-	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
UMN798_RS26190	18017..18313	-	297	WP_001687482.1	hypothetical protein	-
UMN798_RS23715	18797..19318	-	522	WP_010999942.1	hypothetical protein	-
UMN798_RS23720	19994..20212	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
UMN798_RS23725	20214..20519	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
UMN798_RS23730	20521..20811	+	291	WP_001266176.1	hypothetical protein	-
UMN798_RS23735	20808..21329	+	522	WP_000198608.1	hypothetical protein	-
UMN798_RS23740	21364..22146	+	783	WP_000082169.1	site-specific integrase	-
UMN798_RS23745	22155..22868	+	714	Protein_29	EAL domain-containing protein	-
UMN798_RS23750	22872..23381	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
UMN798_RS23755	23375..23860	+	486	WP_000905606.1	membrane protein	-
UMN798_RS26480	24137..24433	-	297	WP_128189354.1	hypothetical protein	-
UMN798_RS23765	24589..25149	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93877	93877

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Antitoxin

• Toxin YoeB (5-84)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T26228 WP_001159863.1 NC_017054:20214-20519 [Salmonella enterica subsp. enterica serovar Typhimurium str. 798]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T26228 NC_017054:20214-20519 [Salmonella enterica subsp. enterica serovar Typhimurium str. 798]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT26228 WP_000813641.1 NC_017054:19994-20212 [Salmonella enterica subsp. enterica serovar Typhimurium str. 798]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT26228 NC_017054:19994-20212 [Salmonella enterica subsp. enterica serovar Typhimurium str. 798]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6