262274

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1981..2540 Replicon plasmid pEC488-KPC-2
Accession NZ_CP109876
Organism Escherichia coli strain EC488

Toxin (Protein)


Gene name relE Uniprot ID U9YB49
Locus tag NQ150_RS25850 Protein ID WP_000421259.1
Coordinates 2265..2540 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U9Y625
Locus tag NQ150_RS25845 Protein ID WP_001178087.1
Coordinates 1981..2265 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ150_RS25840 (46) 46..1077 + 1032 WP_000907852.1 plasmid replication initiator RepA -
NQ150_RS25845 (1981) 1981..2265 + 285 WP_001178087.1 ribbon-helix-helix domain-containing protein Antitoxin
NQ150_RS25850 (2265) 2265..2540 + 276 WP_000421259.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQ150_RS25855 (2646) 2646..2849 + 204 Protein_3 hypothetical protein -
NQ150_RS25860 (3119) 3119..3385 - 267 WP_000627832.1 hypothetical protein -
NQ150_RS25865 (3385) 3385..3879 - 495 WP_015058884.1 hypothetical protein -
NQ150_RS25870 (3935) 3935..4537 - 603 WP_000521606.1 ProQ/FINO family protein -
NQ150_RS25875 (4713) 4713..5765 - 1053 WP_000655519.1 hypothetical protein -
NQ150_RS25880 (5978) 5978..6568 - 591 WP_001401589.1 hypothetical protein -
NQ150_RS25885 (6568) 6568..6822 - 255 WP_000343106.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaKPC-2 - 1..126200 126200


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.45 Da        Isoelectric Point: 9.9324

>T262274 WP_000421259.1 NZ_CP109876:2265-2540 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10488.92 Da        Isoelectric Point: 5.6558

>AT262274 WP_001178087.1 NZ_CP109876:1981-2265 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YB49

Antitoxin

Source ID Structure
AlphaFold DB U9Y625

References