Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1530055..1530667 Replicon chromosome
Accession NC_017053
Organism Streptococcus pyogenes MGAS1882

Toxin (Protein)


Gene name parE Uniprot ID A0A0H3C0F8
Locus tag MGAS1882_RS07520 Protein ID WP_009880846.1
Coordinates 1530332..1530667 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag MGAS1882_RS07515 Protein ID WP_002988079.1
Coordinates 1530055..1530342 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MGAS1882_RS07490 1525235..1526218 - 984 WP_014407847.1 tagatose-bisphosphate aldolase -
MGAS1882_RS07495 1526222..1527151 - 930 WP_014407848.1 tagatose-6-phosphate kinase -
MGAS1882_RS07500 1527197..1527712 - 516 WP_014407849.1 galactose-6-phosphate isomerase subunit LacB -
MGAS1882_RS07505 1527747..1528175 - 429 WP_014407850.1 galactose-6-phosphate isomerase subunit LacA -
MGAS1882_RS07510 1528621..1529394 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
MGAS1882_RS07515 1530055..1530342 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
MGAS1882_RS07520 1530332..1530667 + 336 WP_009880846.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MGAS1882_RS09305 1530819..1531289 + 471 Protein_1420 integrase -
MGAS1882_RS09310 1531651..1531800 + 150 WP_011285175.1 integrase -
MGAS1882_RS07525 1531932..1532324 - 393 WP_002982716.1 30S ribosomal protein S9 -
MGAS1882_RS07530 1532345..1532791 - 447 WP_002982710.1 50S ribosomal protein L13 -
MGAS1882_RS07535 1533009..1533215 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
MGAS1882_RS07540 1533212..1533910 - 699 WP_014407851.1 hypothetical protein -
MGAS1882_RS07545 1534046..1534906 - 861 WP_011529009.1 DegV family protein -
MGAS1882_RS07550 1535003..1535521 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-107)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13204.95 Da        Isoelectric Point: 5.6809

>T26227 WP_009880846.1 NC_017053:1530332-1530667 [Streptococcus pyogenes MGAS1882]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFREVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T26227 NC_017053:1530332-1530667 [Streptococcus pyogenes MGAS1882]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAAGTTTTCCGAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT26227 WP_002988079.1 NC_017053:1530055-1530342 [Streptococcus pyogenes MGAS1882]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT26227 NC_017053:1530055-1530342 [Streptococcus pyogenes MGAS1882]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3C0F8

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References