Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4610048..4610545 Replicon chromosome
Accession NZ_CP109874
Organism Escherichia coli strain EC488

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NQ150_RS22285 Protein ID WP_001173343.1
Coordinates 4610048..4610221 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag NQ150_RS22290 Protein ID WP_000398619.1
Coordinates 4610249..4610545 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ150_RS22275 (4606718) 4606718..4608175 + 1458 WP_022646457.1 dipeptide/tripeptide permease DtpC -
NQ150_RS22280 (4608412) 4608412..4609929 + 1518 WP_022646456.1 lysine--tRNA ligase -
NQ150_RS22285 (4610048) 4610048..4610221 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NQ150_RS22290 (4610249) 4610249..4610545 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NQ150_RS22295 (4610774) 4610774..4611046 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
NQ150_RS22300 (4611058) 4611058..4611288 - 231 WP_001683478.1 4Fe-4S mono-cluster protein YjdI -
NQ150_RS22305 (4611469) 4611469..4613100 + 1632 WP_022646455.1 sensor histidine kinase -
NQ150_RS22310 (4613097) 4613097..4613816 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - papX / papF / papE / papK / papJ / papD / papC / papH / papA / papI 4569434..4610545 41111


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T262264 WP_001173343.1 NZ_CP109874:c4610221-4610048 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT262264 WP_000398619.1 NZ_CP109874:c4610545-4610249 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References