262262

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4466999..4467594 Replicon chromosome
Accession NZ_CP109874
Organism Escherichia coli strain EC488

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag NQ150_RS21560 Protein ID WP_000239581.1
Coordinates 4466999..4467349 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag NQ150_RS21565 Protein ID WP_001223213.1
Coordinates 4467343..4467594 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ150_RS21540 (4462453) 4462453..4463475 - 1023 WP_001298067.1 ABC transporter permease -
NQ150_RS21545 (4463489) 4463489..4464991 - 1503 WP_022646474.1 sugar ABC transporter ATP-binding protein -
NQ150_RS21550 (4465124) 4465124..4466080 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NQ150_RS21555 (4466390) 4466390..4466920 + 531 WP_000055075.1 inorganic diphosphatase -
NQ150_RS21560 (4466999) 4466999..4467349 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
NQ150_RS21565 (4467343) 4467343..4467594 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NQ150_RS21570 (4467806) 4467806..4468147 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NQ150_RS21575 (4468150) 4468150..4471929 - 3780 WP_022646473.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T262262 WP_000239581.1 NZ_CP109874:c4467349-4466999 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT262262 WP_001223213.1 NZ_CP109874:c4467594-4467343 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References