262254

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3739787..3740405 Replicon chromosome
Accession NZ_CP109874
Organism Escherichia coli strain EC488

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NQ150_RS18085 Protein ID WP_001291435.1
Coordinates 3740187..3740405 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NQ150_RS18080 Protein ID WP_000344800.1
Coordinates 3739787..3740161 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ150_RS18070 (3734876) 3734876..3736069 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NQ150_RS18075 (3736092) 3736092..3739241 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NQ150_RS18080 (3739787) 3739787..3740161 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NQ150_RS18085 (3740187) 3740187..3740405 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NQ150_RS18090 (3740577) 3740577..3741128 + 552 WP_000102574.1 maltose O-acetyltransferase -
NQ150_RS18095 (3741244) 3741244..3741714 + 471 WP_022645280.1 YlaC family protein -
NQ150_RS18100 (3741878) 3741878..3743428 + 1551 WP_022645279.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NQ150_RS18105 (3743470) 3743470..3743823 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NQ150_RS18115 (3744202) 3744202..3744513 + 312 WP_000409911.1 MGMT family protein -
NQ150_RS18120 (3744544) 3744544..3745116 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T262254 WP_001291435.1 NZ_CP109874:3740187-3740405 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT262254 WP_000344800.1 NZ_CP109874:3739787-3740161 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References