262252

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3297030..3297735 Replicon chromosome
Accession NZ_CP109874
Organism Escherichia coli strain EC488

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag NQ150_RS15890 Protein ID WP_000539521.1
Coordinates 3297030..3297416 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NQ150_RS15895 Protein ID WP_001280945.1
Coordinates 3297406..3297735 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ150_RS15870 (3293034) 3293034..3293660 + 627 WP_001295292.1 glutathione S-transferase GstB -
NQ150_RS15875 (3293657) 3293657..3294772 - 1116 WP_000554964.1 aldose sugar dehydrogenase YliI -
NQ150_RS15880 (3294883) 3294883..3295266 - 384 WP_000497137.1 biofilm formation regulator BssR -
NQ150_RS15885 (3295479) 3295479..3296804 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
NQ150_RS15890 (3297030) 3297030..3297416 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQ150_RS15895 (3297406) 3297406..3297735 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
NQ150_RS15900 (3297805) 3297805..3299133 - 1329 WP_022645414.1 GGDEF domain-containing protein -
NQ150_RS15905 (3299141) 3299141..3301489 - 2349 WP_022645413.1 EAL domain-containing protein -
NQ150_RS15910 (3301666) 3301666..3302577 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T262252 WP_000539521.1 NZ_CP109874:3297030-3297416 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT262252 WP_001280945.1 NZ_CP109874:3297406-3297735 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References