Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2638379..2639017 Replicon chromosome
Accession NZ_CP109874
Organism Escherichia coli strain EC488

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NQ150_RS12650 Protein ID WP_000813794.1
Coordinates 2638841..2639017 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NQ150_RS12645 Protein ID WP_001270286.1
Coordinates 2638379..2638795 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ150_RS12625 (2633531) 2633531..2634472 - 942 WP_022645667.1 ABC transporter permease -
NQ150_RS12630 (2634473) 2634473..2635486 - 1014 WP_022645666.1 ABC transporter ATP-binding protein -
NQ150_RS12635 (2635504) 2635504..2636649 - 1146 WP_000047466.1 ABC transporter substrate-binding protein -
NQ150_RS12640 (2636894) 2636894..2638300 - 1407 WP_022645665.1 PLP-dependent aminotransferase family protein -
NQ150_RS12645 (2638379) 2638379..2638795 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NQ150_RS12650 (2638841) 2638841..2639017 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NQ150_RS12655 (2639239) 2639239..2639469 + 231 WP_000491567.1 DUF2554 family protein -
NQ150_RS12660 (2639561) 2639561..2641522 - 1962 WP_023909195.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NQ150_RS12665 (2641595) 2641595..2642131 - 537 WP_000429148.1 DNA-binding transcriptional regulator SutR -
NQ150_RS12670 (2642223) 2642223..2643395 + 1173 WP_022645663.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T262250 WP_000813794.1 NZ_CP109874:c2639017-2638841 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT262250 WP_001270286.1 NZ_CP109874:c2638795-2638379 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References