Detailed information of TA system TA026225

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 3259880..3260565
• Replicon: chromosome
• Accession: NC_017052
• Organism: Synechocystis sp. PCC 6803 substr. PCC-N

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A6P1VMJ8
• Locus tag: SYNPCCN_RS15130
• Protein ID: WP_010874101.1
• Coordinates: 3259880..3260275 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SYNPCCN_RS15135
• Protein ID: WP_010874102.1
• Coordinates: 3260287..3260565 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SYNPCCN_RS15115	3255509..3257704	-	2196	WP_010874098.1	phosphoketolase	-
SYNPCCN_RS15120	3257953..3259092	-	1140	WP_010874099.1	site-2 protease family protein	-
SYNPCCN_RS15125	3259222..3259878	+	657	WP_010874100.1	YggS family pyridoxal phosphate-dependent enzyme	-
SYNPCCN_RS15130	3259880..3260275	-	396	WP_010874101.1	type II toxin-antitoxin system VapC family toxin	Toxin
SYNPCCN_RS15135	3260287..3260565	-	279	WP_010874102.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SYNPCCN_RS15140	3260635..3261978	-	1344	WP_010874103.1	FIST C-terminal domain-containing protein	-
SYNPCCN_RS15145	3262106..3264838	+	2733	WP_010874104.1	valine--tRNA ligase	-
SYNPCCN_RS15150	3265060..3265365	-	306	WP_197525966.1	NADH-quinone oxidoreductase subunit NuoK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 15081.50 Da
• Isoelectric Point: 4.5594

>T26225 WP_010874101.1 NC_017052:c3260275-3259880 [Synechocystis sp. PCC 6803 substr. PCC-N]
VKLLLDTQCWLWWFTEPEKLNEDAISQIIDETNEIWLSVASIWEMSIKTSIGKLPLPENIDDYILSRMVKLGAEFLDIKT
RHALQVATLPLHHRDPFDRIIIAQAQTENMLLISADSMFKNYGVSLLWAGV

Nucleotide

• Length: 396 bp

>T26225 NC_017052:c3260275-3259880 [Synechocystis sp. PCC 6803 substr. PCC-N]
GTGAAACTTTTGTTGGATACCCAGTGCTGGTTATGGTGGTTTACTGAGCCGGAAAAATTGAACGAAGATGCAATTTCCCA
GATCATAGATGAGACAAACGAAATATGGCTTTCTGTTGCCAGTATTTGGGAAATGTCAATTAAGACTTCCATCGGTAAAC
TGCCCTTGCCAGAAAATATTGACGACTACATTCTCAGTCGCATGGTGAAATTGGGTGCTGAGTTCCTGGACATTAAAACC
CGCCATGCCCTGCAAGTTGCGACATTGCCCCTACATCACCGTGATCCGTTTGACAGAATTATCATTGCCCAGGCACAAAC
AGAAAATATGCTGCTAATTAGTGCAGATTCAATGTTTAAAAATTATGGAGTCTCTTTGTTATGGGCGGGAGTATAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10084.59 Da
• Isoelectric Point: 4.0201

>AT26225 WP_010874102.1 NC_017052:c3260565-3260287 [Synechocystis sp. PCC 6803 substr. PCC-N]
MIGVSVNPEKLGSTMETVNVDQIEINLPELLYSIKPGEEVIVADQGIPIAKLVPLQRQKSVDRCSSLGVDRGLFVVPDDF
NDPLPNDIWPLS

Nucleotide

• Length: 279 bp

>AT26225 NC_017052:c3260565-3260287 [Synechocystis sp. PCC 6803 substr. PCC-N]
ATGATCGGAGTTAGCGTTAATCCAGAGAAACTAGGATCCACTATGGAGACCGTCAATGTTGACCAAATAGAAATCAATCT
TCCTGAGCTTTTGTACAGTATCAAACCAGGGGAAGAAGTCATCGTTGCTGACCAGGGTATTCCCATTGCTAAGTTGGTTC
CTCTGCAAAGGCAAAAATCCGTGGATCGATGCTCCAGCTTAGGGGTAGATCGAGGATTATTTGTAGTGCCAGATGACTTT
AACGATCCTTTACCAAATGATATTTGGCCATTATCTTGA

Structures

Toxin

• AlphaFold DB: A0A6P1VMJ8