262243

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 934270..934924 Replicon chromosome
Accession NZ_CP109874
Organism Escherichia coli strain EC488

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag NQ150_RS04495 Protein ID WP_000244781.1
Coordinates 934517..934924 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NQ150_RS04490 Protein ID WP_000354046.1
Coordinates 934270..934536 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ150_RS04465 (929548) 929548..930291 + 744 WP_000951948.1 SDR family oxidoreductase -
NQ150_RS04470 (930348) 930348..931781 - 1434 WP_141073354.1 6-phospho-beta-glucosidase BglA -
NQ150_RS04475 (931826) 931826..932137 + 312 WP_001182953.1 N(4)-acetylcytidine aminohydrolase -
NQ150_RS04480 (932301) 932301..932960 + 660 WP_000250269.1 hemolysin III family protein -
NQ150_RS04485 (933037) 933037..934017 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
NQ150_RS04490 (934270) 934270..934536 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NQ150_RS04495 (934517) 934517..934924 + 408 WP_000244781.1 protein YgfX Toxin
NQ150_RS04500 (934964) 934964..935485 - 522 WP_001055874.1 flavodoxin FldB -
NQ150_RS04505 (935597) 935597..936493 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NQ150_RS04510 (936518) 936518..937228 + 711 WP_000715222.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NQ150_RS04515 (937234) 937234..938967 + 1734 WP_000813233.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T262243 WP_000244781.1 NZ_CP109874:934517-934924 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT262243 WP_000354046.1 NZ_CP109874:934270-934536 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References