Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 843037..843872 Replicon chromosome
Accession NZ_CP109874
Organism Escherichia coli strain EC488

Toxin (Protein)


Gene name yeeV Uniprot ID S1EZ92
Locus tag NQ150_RS04020 Protein ID WP_000854726.1
Coordinates 843037..843414 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag NQ150_RS04025 Protein ID WP_001377046.1
Coordinates 843504..843872 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ150_RS03990 (838472) 838472..840007 - 1536 WP_000492888.1 EAL domain-containing protein -
NQ150_RS03995 (840078) 840078..840922 - 845 Protein_785 DUF4942 domain-containing protein -
NQ150_RS04000 (841007) 841007..841093 - 87 Protein_786 hypothetical protein -
NQ150_RS04010 (842418) 842418..842540 - 123 Protein_788 hypothetical protein -
NQ150_RS04015 (842552) 842552..843040 - 489 WP_000761657.1 DUF5983 family protein -
NQ150_RS04020 (843037) 843037..843414 - 378 WP_000854726.1 TA system toxin CbtA family protein Toxin
NQ150_RS04025 (843504) 843504..843872 - 369 WP_001377046.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NQ150_RS04030 (843946) 843946..844167 - 222 WP_000692346.1 DUF987 domain-containing protein -
NQ150_RS04035 (844230) 844230..844706 - 477 WP_001347688.1 RadC family protein -
NQ150_RS04040 (844722) 844722..845207 - 486 WP_029701480.1 antirestriction protein -
NQ150_RS04045 (845262) 845262..846080 - 819 WP_001234642.1 DUF932 domain-containing protein -
NQ150_RS04050 (846180) 846180..846413 - 234 WP_001119719.1 DUF905 family protein -
NQ150_RS04055 (846492) 846492..846947 - 456 WP_000581493.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14164.10 Da        Isoelectric Point: 7.8045

>T262242 WP_000854726.1 NZ_CP109874:c843414-843037 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13584.37 Da        Isoelectric Point: 6.6255

>AT262242 WP_001377046.1 NZ_CP109874:c843872-843504 [Escherichia coli]
VSDTLSGTTHPDDNDDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1EZ92

Antitoxin

Source ID Structure

References