Detailed information of TA system TA026224

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2513964..2514563
• Replicon: chromosome
• Accession: NC_017052
• Organism: Synechocystis sp. PCC 6803 substr. PCC-N

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SYNPCCN_RS11735
• Protein ID: WP_010873447.1
• Coordinates: 2513964..2514341 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SYNPCCN_RS11740
• Protein ID: WP_010873448.1
• Coordinates: 2514342..2514563 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SYNPCCN_RS11720	2509328..2510023	-	696	WP_010873444.1	aldehyde oxygenase (deformylating)	-
SYNPCCN_RS11725	2510281..2511378	-	1098	WP_014407137.1	glucose-1-phosphate thymidylyltransferase	-
SYNPCCN_RS11730	2511620..2513788	+	2169	WP_010873446.1	glycine--tRNA ligase subunit beta	-
SYNPCCN_RS11735	2513964..2514341	-	378	WP_010873447.1	type II toxin-antitoxin system VapC family toxin	Toxin
SYNPCCN_RS11740	2514342..2514563	-	222	WP_010873448.1	DUF2281 domain-containing protein	Antitoxin
SYNPCCN_RS11745	2514628..2515998	-	1371	WP_010873449.1	FADH(2)-oxidizing methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))- methyltransferase TrmFO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (2-124)

Antitoxin

• Domain of unknown function DUF2281 (6-72)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14761.18 Da
• Isoelectric Point: 7.0607

>T26224 WP_010873447.1 NC_017052:c2514341-2513964 [Synechocystis sp. PCC 6803 substr. PCC-N]
MLLDTHTLLWFLDNDIKLPSHLKSLIEAKPKVYVSIVSLWEIAIKLNINKLRLNYAFTDLENLLADLNISVLNITWQHLE
ACRNLPLHHRDPFDRMIIAQAQQHNFSVISKDENFKKYNVNLIWE

Nucleotide

• Length: 378 bp

>T26224 NC_017052:c2514341-2513964 [Synechocystis sp. PCC 6803 substr. PCC-N]
ATGCTACTGGACACCCACACGCTTTTGTGGTTTTTAGATAATGATATAAAACTACCATCACATCTCAAGAGTTTGATTGA
AGCCAAGCCAAAAGTTTATGTCAGCATTGTATCTCTCTGGGAGATTGCCATTAAACTCAACATCAACAAACTAAGGCTTA
ATTACGCTTTTACTGATCTAGAGAATTTACTTGCTGATCTCAATATTTCGGTTTTGAACATCACATGGCAACATTTGGAA
GCTTGTCGCAATTTGCCCTTGCATCATCGAGATCCTTTTGACCGTATGATTATTGCCCAGGCTCAGCAACATAATTTTTC
CGTCATTAGCAAAGACGAAAATTTCAAAAAATACAACGTTAATTTAATCTGGGAATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8355.66 Da
• Isoelectric Point: 4.3855

>AT26224 WP_010873448.1 NC_017052:c2514563-2514342 [Synechocystis sp. PCC 6803 substr. PCC-N]
MTDTALLEKINALPDAMKIEVEHFVEFLLTKQPPVSPVTNDGQKKYRQAGVLKGKIWMADDFDAPLEEMQEYM

Nucleotide

• Length: 222 bp

>AT26224 NC_017052:c2514563-2514342 [Synechocystis sp. PCC 6803 substr. PCC-N]
ATGACAGACACCGCCCTACTAGAAAAGATCAATGCTCTCCCCGATGCCATGAAAATTGAAGTAGAACACTTTGTCGAATT
TCTGCTGACTAAGCAACCACCAGTCAGTCCAGTAACCAATGATGGACAAAAAAAATATCGTCAAGCAGGTGTTCTAAAGG
GGAAAATTTGGATGGCAGATGACTTTGATGCTCCTTTGGAAGAAATGCAGGAGTATATGTAA