262239

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2320320..2321295 Replicon chromosome
Accession NZ_CP109872
Organism Bacillus cereus strain BC38B

Toxin (Protein)


Gene name spoIISA Uniprot ID C3GJ28
Locus tag OK229_RS12040 Protein ID WP_003297560.1
Coordinates 2320320..2321057 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag OK229_RS12045 Protein ID WP_000588712.1
Coordinates 2321170..2321295 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK229_RS12020 (OK229_21840) 2316048..2316830 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
OK229_RS12025 (OK229_21845) 2316952..2318637 - 1686 Protein_2286 alpha-keto acid decarboxylase family protein -
OK229_RS12030 (OK229_21850) 2318744..2319226 + 483 WP_000191912.1 MarR family winged helix-turn-helix transcriptional regulator -
OK229_RS12035 (OK229_21855) 2319394..2320131 + 738 WP_000594156.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
OK229_RS12040 (OK229_21860) 2320320..2321057 + 738 WP_003297560.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
OK229_RS12045 (OK229_21865) 2321170..2321295 + 126 WP_000588712.1 hypothetical protein Antitoxin
OK229_RS12050 (OK229_21870) 2321568..2321849 - 282 WP_001041553.1 hypothetical protein -
OK229_RS12055 (OK229_21875) 2322082..2322207 + 126 WP_264457108.1 hypothetical protein -
OK229_RS12060 (OK229_21880) 2322284..2322460 + 177 WP_000808045.1 stage II sporulation protein SB -
OK229_RS12065 (OK229_21885) 2322604..2324073 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
OK229_RS12070 (OK229_21890) 2324150..2324338 - 189 WP_264457112.1 hypothetical protein -
OK229_RS12075 (OK229_21895) 2324667..2325137 - 471 WP_264457114.1 DUF5065 family protein -
OK229_RS12080 (OK229_21900) 2325314..2325934 + 621 WP_264457116.1 SGNH/GDSL hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.07 Da        Isoelectric Point: 8.2672

>T262239 WP_003297560.1 NZ_CP109872:2320320-2321057 [Bacillus cereus]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT262239 WP_000588712.1 NZ_CP109872:2321170-2321295 [Bacillus cereus]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9EK80

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References