Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 200383..201019 Replicon chromosome
Accession NZ_CP109859
Organism Priestia megaterium strain 207

Toxin (Protein)


Gene name mazF Uniprot ID D5DWT4
Locus tag OHU65_RS01135 Protein ID WP_013055004.1
Coordinates 200669..201019 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID D5DWT3
Locus tag OHU65_RS01130 Protein ID WP_013055003.1
Coordinates 200383..200664 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHU65_RS01105 (OHU65_01105) 195748..196719 + 972 WP_050690798.1 UV DNA damage repair endonuclease UvsE -
OHU65_RS01110 (OHU65_01110) 196728..197330 - 603 WP_221786134.1 rhomboid family intramembrane serine protease -
OHU65_RS01115 (OHU65_01115) 197395..197760 + 366 WP_264409219.1 holo-ACP synthase -
OHU65_RS01120 (OHU65_01120) 197819..198877 + 1059 WP_013055001.1 outer membrane lipoprotein carrier protein LolA -
OHU65_RS01125 (OHU65_01125) 198991..200181 + 1191 WP_221786135.1 alanine racemase -
OHU65_RS01130 (OHU65_01130) 200383..200664 + 282 WP_013055003.1 hypothetical protein Antitoxin
OHU65_RS01135 (OHU65_01135) 200669..201019 + 351 WP_013055004.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
OHU65_RS01140 (OHU65_01140) 201177..202013 + 837 WP_013055005.1 RsbT co-antagonist protein RsbRA -
OHU65_RS01145 (OHU65_01145) 202016..202372 + 357 WP_013055006.1 STAS domain-containing protein -
OHU65_RS01150 (OHU65_01150) 202376..202777 + 402 WP_013055007.1 anti-sigma regulatory factor -
OHU65_RS01155 (OHU65_01155) 202809..203801 + 993 WP_223260212.1 PP2C family protein-serine/threonine phosphatase -
OHU65_RS01160 (OHU65_01160) 203861..204193 + 333 WP_013055009.1 anti-sigma factor antagonist -
OHU65_RS01165 (OHU65_01165) 204190..204675 + 486 WP_025753516.1 anti-sigma B factor RsbW -
OHU65_RS01170 (OHU65_01170) 204641..205435 + 795 WP_013055011.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12991.96 Da        Isoelectric Point: 4.8781

>T262237 WP_013055004.1 NZ_CP109859:200669-201019 [Priestia megaterium]
MVVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVDEALQISVGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10691.22 Da        Isoelectric Point: 8.5339

>AT262237 WP_013055003.1 NZ_CP109859:200383-200664 [Priestia megaterium]
VSEASATTEILVRLPKNLVSELDLMVKQENGNRSDFIHQATKLYLRERKKRHIRESMRRGYMEMAKINLNIASEAFLAEY
EADHTVDRLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0B6AMB9

References