262234

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3512957..3514178 Replicon chromosome
Accession NZ_CP109856
Organism Pseudomonas aeruginosa strain PALA53

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PALA53_RS16115 Protein ID WP_003102740.1
Coordinates 3513600..3514178 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA53_RS16110 Protein ID WP_003088112.1
Coordinates 3512957..3513511 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA53_RS16085 (PALA53_03207) 3508525..3509076 + 552 WP_003132721.1 XRE family transcriptional regulator -
PALA53_RS16090 (PALA53_03208) 3509073..3509471 - 399 WP_023081774.1 NADH-quinone oxidoreductase subunit A -
PALA53_RS16095 (PALA53_03209) 3509484..3509807 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA53_RS16100 (PALA53_03210) 3510138..3510599 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA53_RS16105 (PALA53_03211) 3510604..3512799 + 2196 WP_003114948.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA53_RS16110 (PALA53_03212) 3512957..3513511 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA53_RS16115 (PALA53_03213) 3513600..3514178 + 579 WP_003102740.1 HD domain-containing protein Toxin
PALA53_RS16120 (PALA53_03214) 3514287..3515474 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA53_RS16125 (PALA53_03215) 3515464..3517635 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
PALA53_RS16130 (PALA53_03216) 3517625..3518902 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T262234 WP_003102740.1 NZ_CP109856:3513600-3514178 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT262234 WP_003088112.1 NZ_CP109856:3512957-3513511 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References