Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 602818..603395 Replicon plasmid pESL4.1
Accession NZ_CP109854
Organism Pantoea dispersa strain ESL4

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OH655_RS21900 Protein ID WP_215481170.1
Coordinates 603063..603395 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag OH655_RS21895 Protein ID WP_215481172.1
Coordinates 602818..603063 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH655_RS21875 (OH655_21875) 598181..599134 + 954 WP_153002015.1 carbohydrate kinase family protein -
OH655_RS21880 (OH655_21880) 599138..600220 + 1083 WP_058776100.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -
OH655_RS21885 (OH655_21885) 600339..601748 - 1410 WP_264444192.1 MFS transporter -
OH655_RS21890 (OH655_21890) 601864..602718 + 855 WP_058770343.1 helix-turn-helix transcriptional regulator -
OH655_RS21895 (OH655_21895) 602818..603063 + 246 WP_215481172.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
OH655_RS21900 (OH655_21900) 603063..603395 + 333 WP_215481170.1 endoribonuclease MazF Toxin
OH655_RS21905 (OH655_21905) 603501..603674 + 174 WP_021508895.1 hypothetical protein -
OH655_RS21910 (OH655_21910) 603704..604051 + 348 WP_215481169.1 hypothetical protein -
OH655_RS21915 (OH655_21915) 604091..605284 - 1194 WP_021508893.1 zinc-dependent alcohol dehydrogenase -
OH655_RS21920 (OH655_21920) 605548..606255 + 708 WP_021508892.1 phage antirepressor KilAC domain-containing protein -
OH655_RS21925 (OH655_21925) 606290..606505 - 216 WP_021508891.1 hypothetical protein -
OH655_RS21930 (OH655_21930) 606647..607828 - 1182 WP_058770347.1 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..690879 690879


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-107)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12007.87 Da        Isoelectric Point: 7.8855

>T262230 WP_215481170.1 NZ_CP109854:603063-603395 [Pantoea dispersa]
MVSRFVPDAGDLIWLDFDPTLGHEQGGHRPAVVLSPFAYNNKVGMLLCVPCTTQVKGYPFEVSLVGSRESVALADQVTSI
DWRARKVVKKSHVTADELSEIRAKAKALIG

Download         Length: 333 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8954.26 Da        Isoelectric Point: 4.7377

>AT262230 WP_215481172.1 NZ_CP109854:602818-603063 [Pantoea dispersa]
MTTVTLKKWGNSPSIRIPSSVMQSASLSVNDKLELSVEDGKLILVPLREKVYSLDALLDEITDDNVHDKIDFGPSVGKER
I

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References