Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4123157..4124724 Replicon chromosome
Accession NZ_CP109853
Organism Pantoea dispersa strain ESL4

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OH655_RS19120 Protein ID WP_264441834.1
Coordinates 4123157..4124467 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OH655_RS19125 Protein ID WP_104189496.1
Coordinates 4124467..4124724 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH655_RS19095 (OH655_19095) 4118653..4119315 - 663 WP_058758205.1 6-phosphogluconate phosphatase -
OH655_RS19100 (OH655_19100) 4119467..4120780 + 1314 WP_021506921.1 NCS2 family permease -
OH655_RS19105 (OH655_19105) 4120808..4121572 - 765 WP_264441833.1 phosphopantetheinyl transferase -
OH655_RS19110 (OH655_19110) 4121866..4122375 + 510 WP_031279601.1 flavin reductase family protein -
OH655_RS19115 (OH655_19115) 4122417..4123007 - 591 WP_132466914.1 malonic semialdehyde reductase -
OH655_RS19120 (OH655_19120) 4123157..4124467 - 1311 WP_264441834.1 type II toxin-antitoxin system HipA family toxin Toxin
OH655_RS19125 (OH655_19125) 4124467..4124724 - 258 WP_104189496.1 helix-turn-helix domain-containing protein Antitoxin
OH655_RS19130 (OH655_19130) 4124932..4126296 - 1365 WP_021506917.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
OH655_RS19135 (OH655_19135) 4126377..4128023 - 1647 WP_021506916.1 membrane protein insertase YidC -
OH655_RS19140 (OH655_19140) 4128026..4128283 - 258 WP_071813586.1 membrane protein insertion efficiency factor YidD -
OH655_RS19145 (OH655_19145) 4128247..4128606 - 360 WP_040679622.1 ribonuclease P protein component -
OH655_RS19150 (OH655_19150) 4128622..4128762 - 141 WP_000831330.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49055.20 Da        Isoelectric Point: 8.6907

>T262225 WP_264441834.1 NZ_CP109853:c4124467-4123157 [Pantoea dispersa]
MTELDVYMNGYRTGVFSRAATGAHTFRYYESWLNQPGSRPISLSMPLRHQPYKGAEVYNFFDNLLPDNPEIRARILSRYQ
ASSTQPFDLLAKVGSDTIGALQLLPPDSKPHTVRTIDYRRLSDSELEKILSGYQSGAPLGMLEELTDFRISLAGAQEKTA
LLRIDQQWCLPQGNTPTTHILKLPIGNIQSHSHRIDLSDSVENEWLCTLIAREFGLKVPPCFIVNTGKIKALAVERFDRR
YASDGQWIMRLPQEDFCQVLNVPAAGKYESHGGPGISAIMDYLLNSVNAEQDRYDFMKAQVLFWLLAATDGHAKNFSIFI
EAEGRFRLTPFYDILSIYPVIGGAGLHIRDAKLAMGLNGSKGRKAAIEHIFPRHFIETAKTTKFALTAMAHILDEFRART
PEVIQRVQEQIPAAFPLRVSQTILNGFKARAARLQQ

Download         Length: 1311 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9677.11 Da        Isoelectric Point: 8.5776

>AT262225 WP_104189496.1 NZ_CP109853:c4124724-4124467 [Pantoea dispersa]
MKITSAKQLSSYLKDRRLTEALSQAKVASKIGIRQDTVSSFELQPETTRLDTLFRILAALDLEMEIKPRGLPSAKQDPDG
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References