Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1575606..1576223 Replicon chromosome
Accession NZ_CP109853
Organism Pantoea dispersa strain ESL4

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OH655_RS07055 Protein ID WP_141495245.1
Coordinates 1575606..1575794 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OH655_RS07060 Protein ID WP_058781997.1
Coordinates 1575813..1576223 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH655_RS07040 (OH655_07040) 1572496..1573281 - 786 WP_245001405.1 PhnD/SsuA/transferrin family substrate-binding protein -
OH655_RS07045 (OH655_07045) 1573178..1574245 - 1068 WP_264443640.1 fatty acid desaturase -
OH655_RS07050 (OH655_07050) 1574463..1575485 + 1023 WP_021509376.1 LLM class flavin-dependent oxidoreductase -
OH655_RS07055 (OH655_07055) 1575606..1575794 + 189 WP_141495245.1 type II toxin-antitoxin system HicA family toxin Toxin
OH655_RS07060 (OH655_07060) 1575813..1576223 + 411 WP_058781997.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OH655_RS07065 (OH655_07065) 1576717..1577544 - 828 WP_058771104.1 glycosyltransferase family 8 protein -
OH655_RS07070 (OH655_07070) 1577573..1578955 - 1383 WP_264442901.1 D-arabinono-1,4-lactone oxidase -
OH655_RS07075 (OH655_07075) 1579034..1579675 - 642 WP_021509768.1 TetR family transcriptional regulator -
OH655_RS07080 (OH655_07080) 1579888..1580715 + 828 WP_264442907.1 MetQ/NlpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7000.25 Da        Isoelectric Point: 11.0007

>T262220 WP_141495245.1 NZ_CP109853:1575606-1575794 [Pantoea dispersa]
MDSRSLMAEIKADGWELIRINGSHHHFVHPTKKGLVTIPHPKKDLPIKTVKSIRKQAGLTVH

Download         Length: 189 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14780.06 Da        Isoelectric Point: 4.6268

>AT262220 WP_058781997.1 NZ_CP109853:1575813-1576223 [Pantoea dispersa]
MFYPIAIEAGDETTAYGVTVPDLPGCFSAGDTLEEAVKNAKEAITGHLELMVELGQDIPAVSDLKSLMKSAEFAGYVWVL
VDVDVTRILGGSEKINVTLPKLLIDRIDRCVATHPEFKTRSGFLAQVALERIAKTR

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References