Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4823011..4823619 Replicon chromosome
Accession NZ_CP109851
Organism Pseudomonas aeruginosa strain PALA51

Toxin (Protein)


Gene name PfiT Uniprot ID A0A444LUU5
Locus tag PALA51_RS22750 Protein ID WP_019486378.1
Coordinates 4823011..4823358 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag PALA51_RS22755 Protein ID WP_003114155.1
Coordinates 4823368..4823619 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA51_RS22720 (PALA51_04510) 4818370..4818642 + 273 WP_073651557.1 cysteine-rich CWC family protein -
PALA51_RS22725 (PALA51_04511) 4818642..4819334 + 693 WP_003116517.1 16S rRNA pseudouridine(516) synthase -
PALA51_RS22730 (PALA51_04512) 4819470..4820513 + 1044 WP_003110811.1 L,D-transpeptidase -
PALA51_RS22735 (PALA51_04513) 4820593..4821330 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
PALA51_RS22740 (PALA51_04514) 4821782..4822684 + 903 WP_003116518.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
PALA51_RS22750 (PALA51_04516) 4823011..4823358 - 348 WP_019486378.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA51_RS22755 4823368..4823619 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PALA51_RS22760 (PALA51_04517) 4823833..4824816 - 984 WP_121382283.1 tyrosine-type recombinase/integrase -
PALA51_RS22765 (PALA51_04518) 4824816..4826108 - 1293 WP_269972208.1 hypothetical protein -
PALA51_RS22770 (PALA51_04520) 4826338..4827621 - 1284 WP_023122801.1 zonular occludens toxin family protein -
PALA51_RS22775 (PALA51_04521) 4827625..4827981 - 357 WP_003114150.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4823011..4838622 15611


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12956.72 Da        Isoelectric Point: 4.4212

>T262217 WP_019486378.1 NZ_CP109851:c4823358-4823011 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT262217 WP_003114155.1 NZ_CP109851:c4823619-4823368 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444LUU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References