Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4426592..4427850 Replicon chromosome
Accession NZ_CP109851
Organism Pseudomonas aeruginosa strain PALA51

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag PALA51_RS20710 Protein ID WP_003086331.1
Coordinates 4426592..4427347 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA51_RS20715 Protein ID WP_003086329.1
Coordinates 4427482..4427850 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA51_RS20700 (PALA51_04115) 4421763..4424306 + 2544 WP_003116299.1 acyl-homoserine-lactone acylase QuiP -
PALA51_RS20705 (PALA51_04116) 4424461..4425822 - 1362 WP_073647918.1 DNA recombination protein RmuC -
PALA51_RS20710 (PALA51_04117) 4426592..4427347 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
PALA51_RS20715 (PALA51_04118) 4427482..4427850 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA51_RS20720 (PALA51_04119) 4427923..4429209 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
PALA51_RS20725 (PALA51_04120) 4429265..4430854 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PALA51_RS20730 (PALA51_04121) 4430933..4431409 + 477 WP_003116995.1 hypothetical protein -
PALA51_RS20735 (PALA51_04122) 4431412..4431687 - 276 WP_023099864.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T262216 WP_003086331.1 NZ_CP109851:c4427347-4426592 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT262216 WP_003086329.1 NZ_CP109851:c4427850-4427482 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References