Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3518238..3519459 | Replicon | chromosome |
| Accession | NZ_CP109851 | ||
| Organism | Pseudomonas aeruginosa strain PALA51 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | PALA51_RS16420 | Protein ID | WP_003117667.1 |
| Coordinates | 3518881..3519459 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | PALA51_RS16415 | Protein ID | WP_003117666.1 |
| Coordinates | 3518238..3518792 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PALA51_RS16390 (PALA51_03256) | 3513808..3514359 | + | 552 | WP_003117663.1 | XRE family transcriptional regulator | - |
| PALA51_RS16395 (PALA51_03257) | 3514356..3514754 | - | 399 | WP_003117664.1 | NADH-quinone oxidoreductase subunit A | - |
| PALA51_RS16400 (PALA51_03258) | 3514767..3515090 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| PALA51_RS16405 (PALA51_03259) | 3515421..3515882 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| PALA51_RS16410 (PALA51_03260) | 3515887..3518082 | + | 2196 | WP_003117665.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| PALA51_RS16415 (PALA51_03261) | 3518238..3518792 | + | 555 | WP_003117666.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| PALA51_RS16420 (PALA51_03262) | 3518881..3519459 | + | 579 | WP_003117667.1 | HD domain-containing protein | Toxin |
| PALA51_RS16425 (PALA51_03263) | 3519568..3520755 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| PALA51_RS16430 (PALA51_03264) | 3520745..3522916 | - | 2172 | WP_003114950.1 | type I secretion system permease/ATPase | - |
| PALA51_RS16435 (PALA51_03265) | 3522906..3524183 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21899.72 Da Isoelectric Point: 5.3655
>T262215 WP_003117667.1 NZ_CP109851:3518881-3519459 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDT
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDT
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.67 Da Isoelectric Point: 8.5356
>AT262215 WP_003117666.1 NZ_CP109851:3518238-3518792 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADKALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADKALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|