Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 5299513..5300734 Replicon chromosome
Accession NZ_CP109850
Organism Pseudomonas aeruginosa strain PALA37

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PALA37_RS24745 Protein ID WP_003102740.1
Coordinates 5299513..5300091 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA37_RS24750 Protein ID WP_003088112.1
Coordinates 5300180..5300734 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA37_RS24730 (PALA37_04897) 5294789..5296066 + 1278 WP_270133370.1 TolC family protein -
PALA37_RS24735 (PALA37_04898) 5296056..5298227 + 2172 WP_023106617.1 type I secretion system permease/ATPase -
PALA37_RS24740 (PALA37_04899) 5298217..5299404 + 1188 WP_003139884.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA37_RS24745 (PALA37_04900) 5299513..5300091 - 579 WP_003102740.1 HD domain-containing protein Toxin
PALA37_RS24750 (PALA37_04901) 5300180..5300734 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA37_RS24755 (PALA37_04902) 5300894..5303089 - 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA37_RS24760 (PALA37_04903) 5303094..5303555 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA37_RS24765 (PALA37_04904) 5303886..5304209 + 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA37_RS24770 (PALA37_04905) 5304222..5304620 + 399 WP_023436383.1 NADH-quinone oxidoreductase subunit A -
PALA37_RS24775 (PALA37_04906) 5304617..5305168 - 552 WP_023436384.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T262212 WP_003102740.1 NZ_CP109850:c5300091-5299513 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT262212 WP_003088112.1 NZ_CP109850:c5300734-5300180 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References